Inteum Company
Links
seedsprint
Visible Legacy
RSS
News & Resources
Inteum Company News
Inteum Library
Subscribe
Search Results - jane+trepel+neckers
2
Results
Sort By:
Published Date
Updated Date
Title
ID
Descending
Ascending
Compounds that Interfere with the Androgen Receptor Complex
Abstract: Investigators at the National Institutes of Health (NIH) have discovered compounds that have potential as novel anti-androgen therapeutics. The immunophilin protein FKBP52 is part of a protein complex that helps fold the androgen receptor (AR) protein, a target for treating prostate cancer, and enhances its activity. Disruption of the FKPB52-AR...
Published: 4/8/2024
|
Inventor(s):
Leonard Neckers
,
Jane Trepel Neckers
,
Yeong Kim
,
Aki Iwai
,
Yangmin Ning
,
Marc Cox
,
Johanny Meneses De Leon
,
Heather Balsiger
,
Robert Fletterick
Keywords(s):
androgen receptor protein
,
DIABETES
,
PROSTATE CANCER
Category(s):
Application > Therapeutics
,
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Endocrinology
Treatment of Prostate Cancer Using Anti-androgen Small Molecules
Abstract: Castrate-resistant prostate cancer (CRPC) is characterized by androgen-independent cancer cells that have adapted to the depletion of hormones and continue to grow. Abnormal androgen receptor signaling is known to drive advanced castrate-resistant prostate cancer. The small molecule compounds of this invention are antiandrogens that target...
Published: 4/8/2024
|
Inventor(s):
Jane Trepel Neckers
,
Yeong Kim
,
Sunmin Lee
,
Vineet Kumar
,
Sanjay Malhotra
Keywords(s):
Antiandrogen
,
castrate resistant
,
CRPC
,
PROSTATE CANCER
,
small molecule
,
steroid hormone receptor.
Category(s):
Application > Therapeutics
,
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology