Search Results - inflammation%2fimmunity%2fimmune+therapy

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SapC-DOPS Agents in Imaging Arthritis
(CHMC Ref. Id: 2011-0503) Overview: Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects about 1% of the population and is characterized by the destruction of cartilage and bone ultimately leading to loss of joint function. To date, reliable and non-invasive techniques that accurately measure arthritic disease onset and progression...
Published: 8/7/2018   |   Inventor(s): Sherry Thornton, Xiaoyang Qi, Matthew Flick
Keywords(s): 1 - Diagnostic, Inflammation/Immunity/Immune Therapy, Protein Sci/Structural Bio/Medicinal Che
Category(s): Diagnostics
IL-13 Induced Gene Signature for Eosinophilic Esophagitis
IL-13 Induced Gene Signature for Eosinophilic Esophagitis (CHMC Ref. Id: 2007-0811) Overview: Eosinophilic esophagitis (EE) is an emerging worldwide disease. The current treatment for EE is with swallowed glucocorticoids, however, only a subset of EE patients experience remission from the disease following treatment with topical steroids. Dr....
Published: 8/20/2018   |   Inventor(s): Marc Rothenberg
Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics, Inflammation/Immunity/Immune Therapy
Category(s): Diagnostics
Diagnostic and Prognostic for Crohn's Disease and Ulcerative Colitis
Diagnostic and Prognostic for Crohn's Disease and Ulcerative Colitis (CHMC Ref. Id: 2007-0105) Overview: Several defects in neutrophil function have been noted in Crohn's Disease (CD), including reduced phagocytosis, adhesion, chemotaxis, and oxidative burst. This has been shown to reduce neutrophil accumulation at sites of injury, promoting...
Published: 10/31/2023   |   Inventor(s): Lee Denson, Bruce Trapnell, Kanji Uchida
Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics, Health Serv/Outcomes/Quality/Sys Improv, Inflammation/Immunity/Immune Therapy, Protein Sci/Structural Bio/Medicinal Che, Systems Biology
Category(s): Diagnostics
Diagnostic and Prognostic for Crohn's Disease
Diagnostic and Prognostic for Crohn's Disease (CHMC Ref. Id: 2006-0202) Overview: Standard therapies for IBD include steroids and immunomodulators which lead to a sustained remission in approximately 50% of patients. Currently, there are no reliable predictors of response, leading Dr. Denson and colleagues to prepare and stratify patient...
Published: 2/8/2023   |   Inventor(s): Lee Denson, Bruce Aronow, Huan Xu
Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics, Health Serv/Outcomes/Quality/Sys Improv, Inflammation/Immunity/Immune Therapy, Systems Biology
Category(s): Diagnostics
Diagnostic Classification of Esophagitis
Diagnostic Classificiation of Esophagitis (CHMC Ref. Id: 2005-0401) Overview: Eosinophilic esophagitis (EoE) is an emerging worldwide disease and growing health problem. The primary symptoms of EoE (chest and abdominal pain, dysphagia, heartburn, vomiting, and food impaction) are also observed in patients with chronic esophagitis (CE), including...
Published: 5/16/2024   |   Inventor(s): Marc Rothenberg
Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics, Inflammation/Immunity/Immune Therapy
Category(s): Diagnostics
Critical Role for Eotaxin-3 in Eosinophilic Esophagitis
Critical Role for Eotaxin-3 in Eosinophilic Esophagitis (CHMC Ref. Id: 2004-1003) Overview: Eosinophilic esophagitis (EE) is often confused with gastroesophageal reflux disease (GERD), but it does not typically respond to anti-GERD therapy. Patients with EE typically have elevated levels of eosinophilis in their esophageal tissue and diagnosis...
Published: 5/16/2024   |   Inventor(s): Marc Rothenberg
Keywords(s): Diagnostic Tests, Genomics/Epigenomics, Inflammation/Immunity/Immune Therapy
Category(s): Therapeutics
Novel Genetic Marker for Food Allergy
Despite the similarities of food allergy with other atopic disorders, several characteristics of food allergy are distinct. Food allergy often presents very early in life and sometimes after only a single exposure to the allergen, making this technology attractive as a diagnostic for identifying at-risk infants at birth or soon thereafter.
Published: 5/3/2023   |   Inventor(s): Gurjit Hershey, Amal Assa'ad, Ranajit Chakraborty
Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics, Inflammation/Immunity/Immune Therapy
Category(s): Diagnostics