Inteum Company
Links
Visible Legacy
RSS
News & Resources
Inteum Company News
Inteum Library
Subscribe
Search Results - hongjun+wang
25
Results
Sort By:
Published Date
Updated Date
Title
ID
Descending
Ascending
Fluorescence Polarization Probe for identifying inhibitors of Enterovirus D68 2C
Design of the 2C fluorescence polarization probe Jun14157 and assay. See link to paper below. Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis (AFM), where...
Published: 8/12/2025
|
Inventor(s):
Jun Wang
,
Kan Li
Keywords(s):
Category(s):
Technology Classifications > Infectious Disease
,
Technology Classifications > Research Tools
,
Technology Classifications > Therapeutics
“Y”-shaped symmetric Enterovirus D68 2C inhibitors are antiviral drug candidates
Graphical abstract describing design of “Y”-shaped symmetric 2C inhibitors. See link to paper below. Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68 (EV-D68) infection is linked to the neurological disorder acute flaccid myelitis...
Published: 8/12/2025
|
Inventor(s):
Jun Wang
,
Hiwot Demssie
Keywords(s):
Category(s):
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
,
Medical
New SARS-CoV-2 papain-like protease inhibitor compounds are potent antiviral drug candidates
Binding site of the target papain-like protease of the SARS-CoV-2 virus targeted by these inhibitors. Figure reproduced from inventors’ related paper in Science describing unrelated compounds (link). Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts...
Published: 8/8/2025
|
Inventor(s):
Jun Wang
,
Bin Tan
,
Prakash Jadhav
Keywords(s):
Category(s):
Technology Classifications > COVID-19
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates
Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below. Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Bin Tan
,
Prakash Jadhav
,
Kan Li
Keywords(s):
Antiviral
,
Small molecules
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
Fumaramide SARS-CoV-2 papain-like protease inhibitors are antiviral drug candidates
Published data for lead compound, the fumaramide PLpro inhibitor Jun13728, demonstrate potent inhibition of SARS-CoV2 variants including nirmatrelvir-resistant mutant (light blue). Link to paper below. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Bin Tan
,
Prakash Jadhav
,
Ahmadullah Ansari
,
Francesc Ruiz Figueras
,
Edward Arnold
Keywords(s):
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Therapeutics
Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025
|
Inventor(s):
Jun Wang
,
Prakash Jadhav
,
Bin Tan
,
Haozhou Tan
Keywords(s):
Antiviral
Category(s):
Technology Classifications > COVID-19
,
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
Enterovirus D68 capsid inhibitors as antivirals
Plaque assay results of Jun11-46-1 and Jun11-54-1 against EV-D68 US/MO/14-18947. Invention Summary: Enterovirus D68 (EV-D68) is an RNA virus that mainly affects children and results in moderate to severe respiratory illness, with the most extreme cases resulting in muscle weakness, paralysis, and death. Currently, there are no antivirals...
Published: 1/27/2025
|
Inventor(s):
Jun Wang
,
Yanmei Hu
,
Kan Li
Keywords(s):
Antibacterial
,
Small molecules
Category(s):
Technology Classifications > Healthcare & Life Sciences
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
Wearable tongue tracker for silent speech interfaces
MagTrack is a lightweight, wearable device that utilizes magnetic fields to track tongue movements, enabling silent speech recognition and other applications like speech therapy. Background Silent speech interfaces (SSIs) aim to restore communication for individuals who have lost their voice but retain the ability to articulate, such as those who...
Published: 10/23/2024
|
Inventor(s):
Jun Wang
,
Beiming Cao
Keywords(s):
Category(s):
Life sciences > Diagnostic
,
Life sciences > Imaging
SARS-COV-2 papain-like protease inhibitors as antivirals
Novel compounds and their use as an inhibitor for SARS-CoV-2. Invention Summary: Two oral SARS-CoV-2 antivirals are available, molnupiravir and Paxlovid. However, the limited efficacy, drug-drug interaction, and drug resistance are main challenges facing these two drugs. Additional oral antivirals with novel mechanisms of actions are clearly needed....
Published: 7/9/2025
|
Inventor(s):
Jun Wang
,
Edward Arnold
,
Francesc Ruiz Figueras
,
Prakash Jadhav
,
Bin Tan
,
Ahmadullah Ansari
,
Ashima Chopra
Keywords(s):
Antiviral
,
Small molecules
Category(s):
Technology Classifications > COVID-19
,
Technology Classifications > Infectious Disease
,
Technology Classifications > Therapeutics
,
Technology Classifications > Healthcare & Life Sciences
Novel Main Protease Inhibitors as SARS-CoV-2 Antivirals
This technology encompasses the development of novel inhibitors for the main protease, or Mpro, of SARS-CoV-2. The main protease of SARS-CoV-2 is a validated drug target and could be key to the development of antiviral drugs against the virus. The inhibitors proposed in this technology are notable, as they are potent main protease inhibitors with high...
Published: 2/2/2024
|
Inventor(s):
Jun Wang
Keywords(s):
Category(s):
Technology Classifications > Life Sciences
1
2
3