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Recombinant Enzyme for the Accurate Insertion of Novel DNA Sequences in Eukaryotic Cells
RPI ID: 2022-044-301 Innovation Summary: This gene editing system introduces a recombinant enzyme composed of an HIV integrase (HIV IN) tetramer and two or more Transcription Activator-Like Effectors (TALEs) bound via polypeptide linkers. The enzyme is designed to enable site-specific DNA insertion in eukaryotic cells with minimal off-target effects....
Published: 3/10/2026   |   Inventor(s): Mattheos Koffas, William Lawler
Keywords(s): Gene Integration, Genetic Engineering, Recombinant Proteins, Somatic Cell Editing
Category(s): Biotechnology and the Life Sciences