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Search Results - elsayed+elsayed
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First in class Small Molecule Agonists of the mammalian Relaxin family receptor 1 (RXFP1) and use in treatment of cancer, fibrotic, and vascular disorders (HHS Ref No. E-145-2024-0-US-02)
It is well documented in literature that activation of RXFP1 by relaxin induces: 1) up-regulation of the endothelin system which leads to vasodilation; 2) extracellular matrix remodeling through regulation of collagen deposition, cell invasiveness, proliferation, and overall tissue homeostasis; 3) a moderation of inflammation by reducing levels of inflammatory...
Published: 5/30/2025
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Inventor(s):
Juan Marugan
,
Mark Henderson
,
Kenneth Wilson
,
Wenwei Huang
,
Wenjuan Ye
,
Noel Southall
,
Jiankang Jiang
,
Khalida Shamim
,
Bing Li
,
Alexander Agoulnik
,
Abhijeet Kapoor
,
Joshua Hutcheson
,
Ana Cabrera
,
Irina Agoulnik
Keywords(s):
Category(s):
Application > Therapeutics
,
Application > Research Materials
,
TherapeuticArea > Oncology
,
TherapeuticArea > Cardiology
,
TherapeuticArea > Pulmonology
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TherapeuticArea > Dermatology
,
TherapeuticArea > Reproductive Health
,
TherapeuticArea > Geriatrics
A High-Throughput NMR Method for In-Membrane Ligand-Screening
Advantages: Maintains the original structural and functional properties of receptor proteins Enables high-throughput screening through automated NMR workflows with minimal sample quantities Enhanced Signal-to-Noise Ratio improves detection of ligand-receptor interactions (e.g. binding orientations, kinetics, and dynamics) Applicable to any membrane...
Published: 4/30/2025
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Inventor(s):
Libin Ye
,
Xudong Wang
Keywords(s):
Drug Delivery and Nanomedicine
,
Drug Discovery
Category(s):
Technology Classifications
,
Technology Classifications > Chemistry
,
Technology Classifications > Medical > Biotechnology
Consistent and Compliant Access Control in Microservice Systems
This innovation offers a new way to verify access control policies across microservice systems using constraint modeling. Instead of relying on manual checks or inconsistent logic spread across endpoints, this method introduces a structured and automated approach to ensure secure authorization is applied consistently throughout an entire system. Developers...
Published: 4/23/2025
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Inventor(s):
Tomas Cerny
,
Amr Elsayed
,
Connor Wojtak
Keywords(s):
Category(s):
Technology Classifications > Engineering & Physical Sciences > Communications & Networking
,
Technology Classifications > Software & Information Technology > Security
Lab in the Box: Remote Digitized Clinical Trial and Patient Assessment
Invention Summary: Behavioral and physical assessments are conducted routinely for the diagnosis and proper treatment of individuals. Current assessment methods require patients and subjects to be physically present at laboratories and clinics. This requirement prevents certain sectors of the population from being properly evaluated or...
Published: 3/13/2025
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Inventor(s):
Elizabeth Torres
,
Joe Vero
,
Mona Elsayed
Keywords(s):
Category(s):
Technology Classifications > Software & Copyright
Efficient Decoding Algorithms for Reed-Muller Codes, Recursive Projection-Aggregation and List-Decoding
Efficient Decoding Algorithms for Reed-Muller Codes, Recursive Projection-Aggregation and List-Decoding Princeton Docket # 19-3543-1 Reed-Muller (RM) codes are among the oldest families of error-correcting codes. Compared to polar codes, RM codes have the advantage of having a simple and universal code construction, though RM codes do not yet possess...
Published: 4/10/2025
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Inventor(s):
Min Ye
,
Emmanuel Abbe
Keywords(s):
Category(s):
Computer Science and Information Technology
3D Printed Glass Optical Elements with Controllable Local Transmission and Manufacturing Process
This invention is a method for fabricating complex 3D printed glass microstructures with controllable local transparency, targeting applications such as optical lens design and advanced optical components. It uses polymeric silsesquioxane (PSQ) and two-photon polymerization (TPP) to tune transparency levels by manipulating parameters like laser power,...
Published: 1/21/2025
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Inventor(s):
Rongguang Liang
,
Zhihan Hong
,
Piaoran Ye
,
Douglas Loy
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics > Materials & Fabrication
,
Technology Classifications > Imaging & Optics > Lens & System Design
Acquisition – Software to Control Acquisition of Images for Near-Earth Object Survey Operations
The Acquisition subsystem in the Catalina Sky Survey (CSS) software suite manages the operation of telescopes and instruments to capture data on asteroids and Near-Earth Objects (NEOs). Once areas of the sky are selected for observation, Acquisition takes over, accepting the input from the Planner subsystem and coordinating the telescope, camera, and...
Published: 12/9/2024
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Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Open Source
,
Technology Classifications > Software & Information Technology
Planner – Planning Software for Near-Earth Object Survey Operations
The Planner subsystem in the Catalina Sky Survey (CSS) software suite is designed to help observers efficiently plan nightly asteroid and Near-Earth Object (NEO) observations. By displaying a virtual map of the sky, it helps ensure that areas previously searched, or areas unlikely to be productive, are avoided. The map shows the telescope’s current...
Published: 12/9/2024
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Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Open Source
,
Technology Classifications > Software & Information Technology
Processing – Software to Process and Analyze Images for NEO Survey
The Processing subsystem in the Catalina Sky Survey (CSS) software suite is a streamlined pipeline designed to handle raw images captured by telescopes during asteroid and Near-Earth Object (NEO) surveys. This pipeline processes the images through multiple stages, such as calibrating for optical distortions, extracting star or asteroid positions, and...
Published: 12/9/2024
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Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Open Source
,
Technology Classifications > Software & Information Technology
Monitor – Software to Monitor Status of New and Recently Discovered Objects for NEO Survey
The Monitor subsystem in the Catalina Sky Survey (CSS) software suite is designed to help track the status of newly discovered and recently observed asteroids and Near-Earth Objects (NEOs). It gathers data from various public sources, such as the Minor Planet Center and other NEO survey programs, to provide a clear and prioritized summary of which objects...
Published: 12/9/2024
|
Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Open Source
,
Technology Classifications > Software & Information Technology
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