Search Results - jeremiah+buerer

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Antisense oligonucleotides for rescuing splicing mutations in hotspot exons
An antisense oligonucleotide to rescue multiple splicing mutations in hotspot exons Overview Research by William Fairbrother at Brown University centers around a therapeutic use of ASOs to enhance splicing for various mutations using a single ASO. This can allow for the expansion of treatment options for a broader range of patients with the same underlying...
Published: 10/23/2025   |   Inventor(s): William Fairbrother, Jeremiah Buerer, Chaorui Duan
Keywords(s):  
Category(s): Assay, Therapeutics
Proprietary targeting of Oligonucleotide to vulnerable splicing events to efficiently silence genes
Overview The principle of antisense technology is the sequence-specific binding of an antisense oligonucleotide (ASO) to target mRNA and prevent gene translation. We have found the individual events that are most vulnerable to disruption in cancer cells and developed a method to target these events. We can further restrict the points of vulnerability...
Published: 3/5/2025   |   Inventor(s): William Fairbrother, Jeremiah Buerer, David Glidden
Keywords(s):  
Category(s): Drug Discovery Platform, Therapy Targets