Search Results - chad+dickey(va)+(deceased+-+see+notes)

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Conditional FKBP51 Over-expression Transgenic Mouse
­Advantages: Created a transgenic mice model that allows researchers to precisely control the expression of human FKBP51. Offers a tailored approach to studying psychiatric disorders, enabling the development of personalized treatments. Enhances the understanding of the molecular mechanisms underlying psychiatric disorders such as depression,...
Published: 9/3/2024   |   Inventor(s): Chad Dickey(VA) (DECEASED - See Notes), Laura Blair, Bo Zhang
Keywords(s): Animal Models, Psychiatry / Mental Health
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
Treating Pathological Tau Aggregates by Inhibiting the HSP90 Activator AHA1
Competitive Advantages Targets underlying pathology of Alzheimer’s disease and other tauopathies Cell studies show inhibition of Hsp 90 co-factor Aha1 reduces tau aggregation HSP90 and its co-factors provide novel drug target for future research Summary Pathogenic tau aggregation is one of the major hallmarks associated with...
Published: 2/13/2024   |   Inventor(s): Chad Dickey(VA) (DECEASED - See Notes), Lindsey Shelton, Brian Blagg, John Koren, Laura Blair
Keywords(s):  
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
CyP40 and Amyloid Aggregates
Summary Our researchers have discovered an empirical way of preventing amyloid aggregates. They investigated CyP40 disaggregase capacity by incubating tau or a‐synuclein fibrils with purified recombinant CyP40 and found that CyP40 is capable of disrupting amyloid producing protein and preventing the accumulation of amyloid found in many neurodegenerative...
Published: 8/25/2023   |   Inventor(s): Chad Dickey(VA) (DECEASED - See Notes), Jeremy Baker
Keywords(s):  
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
Hsc70 Inhibitor Effects and Mechanism
Competitive Advantages Novel compounds that bind to the HSP family of proteins Targets conserved proteins Treats various cancers and tauopathies Summary USF researchers have developed several compounds that may be used to reduce tau safely and treat cancer. These compounds bind to heat shock protein 70, specifically the variation...
Published: 8/26/2023   |   Inventor(s): Chad Dickey(VA) (DECEASED - See Notes)
Keywords(s):  
Category(s): Technology Classifications > Cancer
Myricanol Derivatives and Uses Thereof for the Treatment of Neurodegenerative Diseases
Competitive Advantages Causes significant reductions in tau accumulation May treat a variety of tauopathies A natural treatment option Compounds exhibit low toxicity and don’t alter GADPH levels Summary USF researchers have found that myricanol derivatives may be an effective treatment option for many neurodegenerative...
Published: 8/27/2023   |   Inventor(s): Bill Baker, Laurent Calcul, Umesh Jinwal, Chad Dickey(VA) (DECEASED - See Notes)
Keywords(s):  
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
Materials and Methods to Reduce Protein Tau and Treat Neurodegenerative Diseases
Competitive Advantages Exhibited significant tau accumulation reduction in cell models A natural treatment option May treat many different tauopathies A safe and edible therapeutic Summary USF researchers have found that myricanol and myricanone compounds such as bayberry extract may be an effective treatment option for many...
Published: 8/27/2023   |   Inventor(s): Bill Baker, Jeffrey Jones, Matthew Lebar, Chad Dickey(VA) (DECEASED - See Notes)
Keywords(s):  
Category(s): Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience