FKBP51 is a protein that increases with age in both mice and humans. Genetic variations in the FKBP51 gene are linked to conditions like PTSD, bipolar disorder, and major depression, making it a crucial target for research. However, a lack of precise experimental models to manipulate FKBP51 expression and study its impact on depressive behavior has hindered progress in this field.
Our researchers have created a transgenic mouse expressing human FKBP51 linked to a tetracycline response element. This novel model not only enables accurate investigations into the molecular mechanisms but also serves as a powerful platform for screening potential therapeutic agents. Its ability to mimic depressive-like behavior serves as a tool for researchers and pharmaceutical companies aiming to understand and treat mental-health disorders.
Schematic describing targeting vector for transgenic production.