CyP40 and Amyloid Aggregates

Summary

Our researchers have discovered an empirical way of preventing amyloid aggregates. They investigated CyP40 disaggregase capacity by incubating tau or a‐synuclein fibrils with purified recombinant CyP40 and found that CyP40 is capable of disrupting amyloid producing  protein and preventing the accumulation of amyloid found in many neurodegenerative disorders.  


This invention has great therapeutic potential to significantly arrest progression of a number of neurodegenerative diseases.

Competitive Advantages

  • Disrupts amyloid fibril aggregation that is a symptom of various neurodegenerative diseases
  • Potential to treat or prevent the most endemic neurodegenerative disease

Image shows CyP40 significantly lowered level of tau and promoted neuronal health in a mouse model overexpressing P301L tau 

 

Desired Partnerships

  • License
  • Sponsored Research
  • Co-Development
Patent Information: