Search Results - bruce+knutson

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Targeting RNA Polymerase I Protein–Protein Interfaces Using Peptide Inhibitors: A Computational Strategy Powered by PepTelligence, a Comprehensive Peptide Scoring System
PepTelligence is an innovative computational tool designed to evaluate and optimize therapeutic peptides by integrating multiple biochemical and pharmacological factors into a unified scoring system. Background: The development of PepTelligence addresses a significant challenge in peptide drug discovery: the absence of a comprehensive evaluation...
Published: 2/25/2026   |   Updated: 2/24/2026   |   Inventor(s): Maryam Kabiri, Bruce Knutson
Keywords(s): multi-parameter scoring, peptide design, peptide drug discovery, peptide scoring system, structural bioinformatics, Technologies, therapeutic peptides
Category(s): Technology Classifications > Computer Software, Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering
Dual Inhibition of RNA Polymerase I and III as a Novel Strategy for Targeting Ribosome Biogenesis in Cancer
A specially designed peptide blocks two key enzymes needed for ribosome production in cancer cells, shutting down their protein-making machinery and offering a new, more effective way to treat cancer and prevent drug resistance. Background: Ribosome biogenesis is a fundamental cellular process involving the coordinated synthesis of ribosomal RNA...
Published: 3/26/2026   |   Updated: 2/19/2026   |   Inventor(s): Haleigh Pascual, Bruce Knutson
Keywords(s): cancer, Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Therapeutics and Vaccines