Search Results - her2

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Her2 Monoclonal Antibodies, Antibody Drug Conjugates as Cancer Therapeutics
Abstract: Antibody drug conjugates (ADC) can demonstrate high efficacy as cancer therapeutics, however, much more can be done to improve their efficacy and safety profile. Site-specific antibody drug conjugation is a promising way to do this. Scientists at the NCI’s Laboratory of Experimental Immunology have identified a fully human monoclonal antibody,...
Published: 5/22/2024   |   Inventor(s): Dimiter Dimitrov, Zhongyu Zhu, Pradman Qasba, Boopathy Ramakrishnan
Keywords(s): ADC, antibody drug conjugate, Dimitrov, HER2, Her2 positive, Her2-overexpression
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology
Anticancer Agents for Triple-Negative Breast Cancers
Selectively Kills EGFR+, HER2+, and HER+3 Tumors via New Mechanism, Enabling These Tumors to Overcome Resistance to Current TherapyThis first-in-class compound selectively kills cancer cells without harming normal tissues. The Epidermal Growth Factor Receptor (EGFR) family members -- EGFR, Human Epidermal Growth Factor Receptor-2 (HER2) and Human Epidermal...
Published: 11/19/2021   |   Inventor(s): Brian Law, Ronald Castellano
Keywords(s): Akt, breast cancer, Compound, EGFR, Her2, HER2/neu receptor, Therapeutic
Category(s): Technology Classifications > Human Health Care > Therapeutics