NU 2013-018
Inventors
Runye H. Zha
Ming Zhang
Samuel I. Stupp*
Short Description
The design, synthesis and use of peptide amphiphiles with potent anti-angiogenesis properties for inhibiting tumor growth.
Background
Angiogenesis, i.e. the sprouting of new blood vessels from pre-existing vasculature, is essential for the progression of tumor malignancy. Thus, potent angiogenesis inhibitors such as maspin, a class II tumor suppressor protein, offer promising therapeutics either in conjunction with, or in place of traditional chemotherapy. However, synthesis and purification of whole protein therapeutics continues to present several prohibitive challenges; thus, the development of protein-mimetics may be a game changing approach to anti-angiogenic therapy.
Abstract
Researchers at Northwestern have designed and synthesized a supramolecular peptide amphiphile (PA) nanostructure that exhibits potent anti-angiogenic bioactivity in vitro and in vivo. This maspin-mimetic peptide-based amphiphile (MMPA) consists of the maspin g-helix peptide motif, a site associated with inhibiting migration, attached to hydrophobic and peptide moieties which promote rational nanostructure self-assembly in aqueous solution. These MMPA nanostructures show potent anti-angiogenic activity (p
IP Status
Issued US Patent No. 9,556,232.