Novel Method of Enzymatic Plaque Digestion

NU 2008-157 

 

Inventors

Guillermo Ameer* 

Melina Kibbe*

Jason Rubenstein 

 

Abstract

Northwestern investigators have developed a novel plaque digestion composition to remove atherosclerotic plaque with minimal trauma to the arterial wall and minimal risk to the patient. No such approach has ever been utilized in patients. Balloons and mechanical blades are not required which avoids all potential risk of inducing arterial injury and at the same time providing a safe approach. Additionally, all particular matter is aspirated, thereby avoiding embolization of atherosclerotic plaque, a problem that all of the above mentioned atherectomy devices face. Thus, this approach expects to provide superior outcomes associated with significantly reduced failure rates compared to currently available modalities, thereby diminishing the need for reintervention, improving patient outcomes, and reducing overall health care costs. 

 

Applications

  • Atherosclerosis

 

Advantages

  • Minimizes vascular trauma
  • Reduces potential for reintervention
  • Improved safety over current provisions
  • Removes plaque

 

IP Status

Issued US Patent No. 9,707,281.

 

 

Patent Information: