Closed-Loop Implantable System for Automated Opioid Overdose Detection and Reversal

NU 2019-073

INVENTORS

  • John Rogers (Northwestern University)*
  • Robert Gereau (Washington University, St Louis)*

SHORT DESCRIPTION

This wireless device, the size of a pacemaker, is implanted to monitor oxygen levels. Below a specific threshold, it sends an alert to warning notification on a mobile app, then automatically releases naloxone to prevent fatal outcomes, and contacts 911 with the person's location. It targets high-risk patients and the healthcare market seeking rapid intervention solutions.

BACKGROUNDClosed-Loop Implantable System for Automated Opioid Overdose Detection and Reversal

Over 2 million Americans live with opioid use disorders and face a high risk of overdose. Current treatments suffer from delays due to slow emergency response and waiting times for EMS arrival. These delays can prove fatal, highlighting the need for technologies that provide immediate intervention during overdose events.

ABSTRACT

This invention is an autonomous implantable device that detects opioid overdose in real time and instantly administers naloxone to reverse the overdose. It continuously monitors physiological parameters and uses Bluetooth connectivity to alert first responders for additional medical support. The system integrates detection and drug release and achieves immediate antidote delivery under controlled laboratory conditions.

MARKET OPPORTUNITY

The global market for opioid use disorder (OUD) treatment was valued at $3.62 billion in 2024 and is projected to reach $7.51 billion by 2032, growing at a CAGR of 9.7% (Source: Fortune Business Insights, 2024). This market is driven by the severe public health crisis, with the U.S. alone reporting that the opioid epidemic cost its economy nearly $1.5 trillion in 2020 (Source: U.S. Congress Joint Economic Committee). The system addresses a critical gap by reducing treatment delays and saving lives.

DEVELOPMENT STAGE

TRL 4 - Prototype Validated in Lab: The system has demonstrated key functions by detecting overdose conditions and releasing naloxone in a controlled laboratory environment.

APPLICATIONS

  • Drug delivery: Provides automatic, immediate drug naloxone administration upon overdose detection.
  • Platform technology: implantable device for monitoring a physiological status and administering drugs 

ADVANTAGES

  • Instant drug delivery: Eliminates delays by administering antidote immediately upon detection.
  • Bluetooth integration: Alerts first responders to ensure timely follow-up care.
  • Implantable design: Enhances patient compliance compared to external wearable devices.

PUBLICATIONS

IN THE NEWS

IP STATUS

US Patent Pending (Application #18/567,428)

 

Patent Information: