Invention Summary:
Free radicals have been identified as major sources of oxidative stress in cells leading to DNA damage. This increased oxidative stress has been implicated in various deleterious conditions including cardiovascular diseases, neurodegenerative diseases, and cancer, while also contributing to the physiology of ageing. Antioxidants can counteract the oxidative stress; however, they are usually not in sufficient levels to overcome the damage from oxidative stress accumulation. Therefore, there has been much effort in the development of topical antioxidants with photoprotective and therapeutic efficacy.
Researchers at Rutgers University have designed a novel antioxidant composition with glycolic linkers. The antioxidants include p-coumaric acid, ferulic acid, and sinapic acid. These polymers can be fine-tuned for a desired antioxidant release profile, enhanced hydrophilicity, and other properties (thermal, mechanical, etc.) by altering the polymer chemical composition. The bioactive release rate can be altered for a tunable release delivery system, allowing for increased bioactive release. Overall, these tunable polymers could improve the quality, aesthetics, and performance of a product.
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Intellectual Property & Development Status: Patent US9,862,672B2. Available for licensing and/or research collaboration.