Novel Antiviral Compounds to Treat Enterovirus Infections
SUMMARY
Researchers in UCLA Department of Molecular & Medical Pharmacology have used a rapid, live virus assay to develop potent enterovirus inhibitors.
BACKGROUND
Human enteroviruses (EVs) are a genus of more than 110 serologically distinct, small, non-enveloped RNA viruses responsible for poliomyelitis (viral infection of the nerves), encephalitis (viral infection of the brain), acute heart failure, meningitis, and other life-threatening infections. Enteroviruses cause 10 to 15 million infections and tens of thousands of hospitalizations in the US each year. While immunization has curtailed circulation of the polioviruses in most of the world, other EVs (e.g. coxsackieviruses, echoviruses, and numbered EVs) continue to cause substantial morbidity and mortality with no effective medications to treat them. Successful development of antiviral therapeutics against large numbers of medically relevant enteroviruses could save many lives and reduce healthcare costs and burdens associated with viral infections.
INNOVATION
Researchers in UCLA’s Department of Molecular & Medical Pharmacology and Department of Chemistry & Biochemistry have used a rapid, live virus assay to help design and test potent enterovirus inhibitors. The compounds are unlike any previously described inhibitors of EV replication, and exhibit very potent activity against coxsackievirus B. Using these novel analogues, the researchers designed and synthesized several EV growth inhibitors that exhibit more potent activity and broader spectrum of activity than currently available therapeutics. The antiviral agents can be altered and expanded to other members of picornavirus family, or other viruses with similar replication strategies. These antiviral agent derivatives could become the basis for development of medications to combat different classes of viral infections.
APPLICATIONS
- Treatment of various EV infections
- Development of antiviral agents for treatment of other viruses
ADVANTAGES
- Compounds exhibit potent antiviral activity
- Compounds exhibit a broad range of antiviral activity
- Compounds are applicable to large number of medically relevant enteroviruses
- Antiviral analogues have the potential to be expanded to treat other families of viruses
STATE OF DEVELOPMENT
Various novel antiviral agents have been designed and synthesized. Plaque assay and virus cytopathic effect assay will be performed on representative enteroviruses such as coxsackieviruses, echoviruses and polioviruses to evaluate the agents’ antiviral activities.