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Search Results - zhangyu+guan
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Multi-material electrospinning system for 3D-printed fiber architectures
Background Electrospinning and additive manufacturing have become increasingly important in fields such as biotechnology, pharmaceuticals, and tissue engineering, where there is growing demand for complex fiber architectures and multifunctional material systems. However, traditional electrospinning methods struggle to meet the precision, scalability,...
Published: 4/25/2025
|
Inventor(s):
Mohammed Maniruzzaman
,
Yu Zhang
,
Faez Alkadi
,
Ishaan Duggal
Keywords(s):
Category(s):
Life sciences > Therapeutics > Manufacturing platform
Advanced multi-channel controlled pneumatic printheads for 3D printing and particle fabrication
MAGIC printheads are customizable multi-channel pneumatic systems for 3D printing that create precise pharmaceutical and biological micro-particles. They enable controlled mixing and extrusion, accommodate various materials, and enhance drug delivery and biomedical applications. Background Producing micro- and nanoparticles for pharmaceutical and...
Published: 2/20/2025
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Inventor(s):
Mohammed Maniruzzaman
,
Yu Zhang
,
Faez Alkadi
Keywords(s):
Category(s):
Life sciences > Therapeutics > Manufacturing platform
Safe Explicable Robot Planning
Background Effective human-robot interaction must be informed by human expectations and knowledge of the world, including how robots are expected to act/interact in various situations. However, knowledge about the robot may be inconsistent with the ground truth, which can result in the robot not meeting expectations, and the interaction integrity being...
Published: 2/13/2025
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Inventor(s):
Yu Zhang
,
Akkamahadevi Hanni
,
Andrew Boateng
Keywords(s):
Category(s):
Physical Science
,
Applied Technologies
,
Wireless & Networking
,
Artificial Intelligence/Machine Learning
3D-printed biosensors for high-sensitivity molecular detection
This invention describes the creation of highly sensitive biosensors through 3D printing using stereolithography (SLA). These biosensors, made from a biopolymer blend with specific monomers and a photoinitiator, are functionalized with recognition molecules to detect small and large analytes, including disease markers, in commercial well plates. Background Additive...
Published: 7/26/2024
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Inventor(s):
Mohammed Maniruzzaman
,
Yu Zhang
Keywords(s):
Category(s):
Life sciences > Research tools > Tool/assay/screening platform
,
Life sciences > Diagnostic
“Bio-Flex”: advanced formulation for sustainable stereolithography (SLA)
Background/problem Stereolithography (SLA) 3D printing has transformed the biomedical field with creation of highly accurate, patient-specific medical devices such as tissue scaffolds, implants, and surgical tools. This technology leverages computer-aided design and medical imaging data to produce structures with precise geometries at submicron scales....
Published: 7/26/2024
|
Inventor(s):
Mohammed Maniruzzaman
,
Yu Zhang
,
Anqi Lu
Keywords(s):
Category(s):
Life sciences > Medical technology > Medical devices
,
Life sciences > Therapeutics > Drug delivery
Thermal Control During Additive Manufacturing
THE CHALLENGE Additive manufacturing (AM) has emerged as a powerful tool within engineering. Many AM and coating processes rely on thermal input to soften or melt the materials involved in processing. However, this melting or softening typically results in a higher thermal gradient between deposited material and the workpiece, commonly resulting in...
Published: 12/20/2023
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Inventor(s):
Robert Griffiths
,
David Garcia
,
Hang Yu
Keywords(s):
Category(s):
EXPERIMENT--DO NOT USE
,
Technology Classifications > Additive Manufacturing
FIBP Knockout Potentiates Therapeutic Effects of T-cell Based Therapies in Solid Tumors
Abstract: Despite recent breakthroughs in cancer immunotherapy, T-cell based therapies achieve limited efficacy in solid tumors. Immunosuppression, antigen escape and physical barriers to entry into solid tumors are issues faced. Identifying regulators in T-cell dysfunction remains challenging due to limitations of current screening platforms. Using...
Published: 4/22/2025
|
Inventor(s):
Peng Jiang
,
Yu Zhang
Keywords(s):
adoptive cell therapy
,
Cancer Immunotherapy
,
cholesterol metabolism
,
Computational Model
,
FGF1 Intracellular Binding Protein
,
FIBP
,
Jiang
,
solid tumors
,
T-Cell based Therapy
,
T-Cell Resilience
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology
,
Application > Therapeutics
Automated Flight Planning System for Urban Air Mobility
Advantages: AFPS uses advanced algorithms for airspace management and conflict resolution, ensuring safety in high-density Urban air mobility (UAM) environments. AFPS enhances UAM efficiency by optimizing airspace use and generating conflict-free flight paths. AFPS allows Providers of Service for UAM (PSU) to provide seamless airspace and traffic...
Published: 9/3/2024
|
Inventor(s):
Yu Zhang
Keywords(s):
Industrial Applications
,
Transportation
Category(s):
Technology Classifications > Engineering > Drones
,
Technology Classifications > Engineering > Mechanical Engineering
,
Technology Classifications > Engineering > Sensors
,
Technology Classifications > Energy & Environment
Method for 3D Nonlinear Structured Illumination Super-resolution Imaging
Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...
Published: 4/3/2023
|
Inventor(s):
Leilei Peng
,
Yu Li
,
Han Zhang
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics
,
Technology Classifications > Imaging & Optics > Medical Imaging
,
Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry
Production of cyclopeptibodies with high target affinity and specificity that can be used as a replacement for antibodies
Background Antibodies find widespread use as therapeutic agents and for diagnostic, imaging, and immunodetection applications. Major limitations of antibodies, however, are their complex structure, limited stability, poor tissue penetration, complex manufacturing process, and associated high costs of production. Despite their numerous and important...
Published: 5/7/2024
|
Inventor(s):
Rudi Fasan
,
Yu Gu
Keywords(s):
Category(s):
Therapeutic
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