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IRF4-Engineered T Cells Induce T Cell Function As a Treatment Strategy for Solid Tumors
Asset/Technology Type
New Therapeutic Strategy
Description of Invention
The invention includes compositions and methods of delivering therapeutic anti-tumor T cells by forcing them to overexpress interferon regulatory factor (IRF4) as a treatment for various solid tumors, including but not limited to melanoma, lymphoma, and colon cancer. The inventors...
Published: 4/11/2025
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Inventor(s): Wenhao Chen, Xian Li
Keywords(s):
Category(s): Clinical Area > Transplantation, Clinical Area > Cancer, Clinical Area > Metabolic Disease, Inflammation, and Immunology, Research Area > Cancer, Research Area > Immunobiology and Inflammation, Technology Classifications > Therapeutic > Cell and Gene Therapies
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Recovering Critical Elements from Acid Mine Drainage
THE CHALLENGE
The demand for certain elements, such as Manganese (Mn), Cobalt (Co), and Nickel (Ni), has surged in recent years due to the rapid growth of battery production for electric vehicles and utility-scale energy storage. The United States government has deemed Co, Ni, and Mn critical elements, primarily because of the country’s high...
Published: 6/26/2024
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Inventor(s): Wencai Zhang, Qi Li, Rick Honaker
Keywords(s):
Category(s): Technology Classifications > Energy, Technology Classifications > Mining and Recycling, Technology Classifications, Technology Classifications > Chemicals/Materials
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Intelligent Multi-Beam Medium Access Control in Ku-Band for Mission-Oriented Mobile Mesh Networks
The Problem:
There are existing similar technologies, but these technologies are not designed for mobile mission-oriented applications. The use of Ku-band frequency on two separate information transmission levels reduces interference common with current multi-beam antennas. Also, the Ku-band frequency is not the currently used frequency range...
Published: 2/27/2023
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Inventor(s): Fei Hu, xI Li, Sunil Kumar
Keywords(s):
Category(s): Technology Classifications > Communication
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PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 2/18/2025
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Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
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Scanning Tunneling Microscope (STM) Algorithm That Increases Accuracy of Scan Results
Requires No Additional Hardware, Determines Accurate Position of Atoms on Material’s Surface By Combining Multiple Scans This algorithm combines multiple scans from a scanning tunneling microscope to reduce or eliminate errors in individual scans without any hardware upgrades. Scanning tunneling microscopes are electron microscopes that show 3D...
Published: 6/27/2021
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Inventor(s): Yunmei Chen, Xiaoguang Zhang, Hao Zhang, Xianqi Li
Keywords(s): Image Analysis, Image Processing, Image Registration, microscopy
Category(s): Technology Classifications > Engineering > Instrumentation-Sensors-Photonics, Technology Classifications > Research Tools
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Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023
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Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
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All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023
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Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li
Keywords(s):
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
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