Search Results - william+earnshaw

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High-throughput Assay to Identify New Cancer Drugs
Abstract:  The National Cancer Institute seeks parties interested in collaborative research to evaluate or commercialize a diagnostic tool that can identify new drugs that increase chromosome instability.  Although chromosomal instability is generally thought of as a driver of tumor growth, a threshold level exists where CIN becomes a barrier to tumor...
Published: 4/8/2024   |   Inventor(s): Vladimir Larionov, William Earnshaw
Keywords(s): chromosome instability (CIN), drug discovery, green fluorescent protein labeled chromosome, high-throughput assay
Category(s): Application > Research Materials, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Rapid Methods for Human Artificial Chromosome (HAC) Formation
Abstract: Gene therapy is a promising strategy to treat a wide range of human diseases, and several gene therapy vectors have been developed to deliver these novel treatments. However,  risks and challenges of using these vectors remain, such as: gene integration, potential infection, immune response and maintaining long term, stable gene expression....
Published: 4/8/2024   |   Inventor(s): Vladimir Larionov, William Earnshaw, Reto Gassman, Stefanie Kandels-Lewis, Hiroshi Masumoto, Megumi Nakano, Vladimir Noskov, Natalay Kouprina, J. Carl Barrett
Keywords(s): Alphoid DNA arrays, Centromere Seeding, Engineered Centromeric Sequences, Gene expression/delivery system, GENE THERAPY, Human artificial chromosomes (HACs), Mammalian Artificial Chromosomes Larionov, RCA, Recombinational Amplification of Repeats RAR, Rolling-circle amplification, TAR-NV, Transformation-Associated Recombination targeting vector
Category(s): TherapeuticArea > Oncology, Application > Research Materials, Collaboration Sought > Collaboration, Collaboration Sought > Licensing
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 7/30/2024   |   Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources