Search Results - walter+becker

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Broad Applications of PROTACS for Targeted Protein Degradation Employing a Molecular Glue-Linker-Warhead Approach
This technology is a high-affinity E3-ligase binder, which has been optimized toward the specific proteolysis targeting chimera (PROTAC) mediated degradation of particular proteins. A PROTAC is a heterobifunctional molecule composed of two active domains and a linker, capable of removing specific unwanted proteins. This technology opens the door for...
Published: 8/27/2025   |   Inventor(s): Christopher Hulme, Kevin Schofield, Samantha Rokey, Aidan McMahon, Sean Ginn, Alessandra Fistrovich, Walter Becker, Gerrit Wilms, Katharina Schwandt
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
DYRK/CLK PROTACS
This invention describes a set of novel molecules that target and degrade DYRK/CLK for several potential therapeutic purposes. Background: Proteolysis-targeting chimeric molecules (PROTACs) are small molecules used to decrease a gene’s protein expression by targeting the protein for ubiquitination and degradation after it is created. This mechanism...
Published: 11/16/2023   |   Inventor(s): Christopher Hulme, Kevin Schofield, Walter Becker, Garrit Wilms
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics