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Broad Applications of PROTACS for Targeted Protein Degradation Employing a Molecular Glue-Linker-Warhead Approach
This technology is a high-affinity E3-ligase binder, which has been optimized toward the specific proteolysis targeting chimera (PROTAC) mediated degradation of particular proteins. A PROTAC is a heterobifunctional molecule composed of two active domains and a linker, capable of removing specific unwanted proteins. This technology opens the door for...
Published: 8/27/2025
|
Inventor(s):
Christopher Hulme
,
Kevin Schofield
,
Samantha Rokey
,
Aidan McMahon
,
Sean Ginn
,
Alessandra Fistrovich
,
Walter Becker
,
Gerrit Wilms
,
Katharina Schwandt
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Small Molecules
,
Technology Classifications > Life Sciences > Therapeutics