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Search Results - therapeutics+%3e+oncology
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Regulated Gene Expression During Differentiation of Mature T Cells (UCLA Case No. 2022-147)
UCLA researchers from the Department of Pathology & Laboratory Medicine have developed a process to genetically modify stem cells to express transgenes in a regulated, stage-specific manner, avoiding the negative consequences of transgene expression during T cell development. Contact UCLA Technology Development Group for more information.
Published: 1/27/2026
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Inventor(s):
Gay Crooks
,
Donald Kohn
Keywords(s):
Category(s):
Therapeutics > Gene Therapy And Editing
,
Therapeutics > Stem Cells And Regenerative Medicine
,
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
,
Therapeutics > Inflammation And Inflammatory Diseases
Enhancing T Cell Production in Vitro From Stem and Progenitor Cells (UCLA Case No. 2022-257)
UCLA researchers from the Department of Pathology and Laboratory Medicine have developed an innovative differentiation method to increase T cell production for T cell immunotherapy. Contact UCLA Technology Development Group for more information.
Published: 1/27/2026
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Inventor(s):
Gay Crooks
,
Christopher Seet
Keywords(s):
Category(s):
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
Peri-Operative Cancer Therapy to Preserve Anti-Tumor Immune Surveillance (UCLA Case No. 2025-257)
UCLA Researchers from the Department of Surgery have developed a novel approach to preserve anti-tumor immunity in the peri-operative period through modulation of clinically relevant molecular and cellular targets. BACKGROUND: Surgical resection with curative intent is a mainstay of treatment for many solid tumors. However, even when the tumor is macroscopically...
Published: 1/12/2026
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Inventor(s):
Tyler McCaw
Keywords(s):
Category(s):
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
Generation of Therapeutic Human Anti-Trop-2 Extracellular Domain Antibodies (UCLA Case No. 2026-026)
UCLA researchers from the Department of Molecular and Medical Pharmacology and the Department of Microbiology, Immunology and Molecular Genetics have developed a panel of human antibodies and chimeric antigen receptors targeting Trop-2, providing diagnostic and therapeutic resources for targeting Trop2-driven cancer. BACKGROUND: Trophoblast cell surface...
Published: 12/23/2025
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Inventor(s):
Tanya Stoyanova
,
Owen Witte
Keywords(s):
Category(s):
Diagnostic Markers > Cancer
,
Diagnostic Markers > Targets And Assays
,
Life Science Research Tools > Antibodies
,
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
Combinatorial RNA-LNP Immunotherapy for Enhanced Pattern Recognition Receptor (PRR) Engagement, Targeted Dendritic Cell (DC) Activation, and Versatile (UCLA Case No. 2025-237)
UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a cancer immunotherapy platform that uses lipid nanoparticle (LNP) delivery of modified RNA constructs to activate dendritic cells, enhance CD8+ T-cell priming, and drive potent anti-tumor immunity. BACKGROUND: Effective cancer immunotherapy requires robust activation...
Published: 12/23/2025
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Inventor(s):
Caius Radu
Keywords(s):
Category(s):
Therapeutics > Oncology
,
Therapeutics > Vaccines
,
Therapeutics > Infectious Diseases
B Cell-Based Assay to Expand Antigen-Specific T Cells (UCLA Case No. 2025-288)
UCLA researchers from the Department of Medicine have developed a novel B cell-based assay to expand antigen-specific T cells, allowing for an efficient, patient-specific platform to generate tumor antigen-specific T cells. BACKGROUND: Adoptive T cell therapies have emerged as a promising strategy for cancer immunotherapy, enabling the expansion of...
Published: 11/6/2025
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Inventor(s):
Yuanyuan Tong
,
Willy Hugo
,
Maureen Su
,
Melissa Lechner
,
Robert Prins
Keywords(s):
Category(s):
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
Silyl Ether Enables Chemoproteomic Interaction and Target Engagement (SEE-CITE) (UCLA Case No. 2024-194)
UCLA researchers from the Department of Biological Chemistry have developed a chemoproteomic platform for high-coverage, site-specific mapping of small-molecule–protein interactions using a cleavable silyl ether–based photoaffinity probe design. BACKGROUND: Small molecule drugs rely on specific and selective interactions with protein targets...
Published: 11/4/2025
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Inventor(s):
Keriann Backus
Keywords(s):
Category(s):
Life Science Research Tools > Mass Spectrometry
,
Life Science Research Tools > Research Methods
,
Therapeutics > Oncology
Pancreas Cancer Immunotherapy using Cationic Lipid and Polymer Nanocarriers for co-delivery of KRAS Neoantigens and STING or other immunomodulators to boost the Cancer Immunity Cycle and Treat Liver Metastasis (UCLA Case No. 2024-076)
UCLA researchers have developed a translational immunotherapy platform that leverages nanoparticle-based delivery of tumor-associated signals and immune-stimulatory molecules to drive localized immune activation in metastatic pancreatic cancer. This approach is designed to initiate de novo immune priming and recondition the tumor microenvironment in...
Published: 10/29/2025
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Inventor(s):
Andre Nel
Keywords(s):
Category(s):
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
,
Therapeutics > Vaccines
,
Platforms > Drug Delivery
Cannabis Limits Cancer Stem Cell Growth in Poorly Differentiated Cancers (UCLA Case No. 2020-869)
Contact UCLA Technology Development Group for more information.
Published: 10/23/2025
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Inventor(s):
Anahid Jewett
Keywords(s):
Category(s):
Therapeutics > Oncology
Sonicated Osteoclasts as Drugs to Increase NK Expansion and Function in Patients and in Manufacturing of NK Cells (Case No. 2024-272)
UCLA researchers from the Department of Dentistry have developed an innovative method to manufacture, expand and improve the function of natural killer cells by using sonicated osteoclasts for cancer immunotherapy. BACKGROUND: Natural killer cells (NK cells) are immune cells that recognize and combat pathogens and cancer cells. NK cell immunotherapy...
Published: 10/23/2025
|
Inventor(s):
Anahid Jewett
Keywords(s):
Category(s):
Therapeutics > Oncology
,
Therapeutics > Immunology And Immunotherapy
,
Therapeutics > Oncology
> Oncology Immunotherapy
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