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C41 Analogs

This invention relates generally to neurodegenerative diseases and conditions, such as Alzheimer’s Disease, characterized with dysfunctional energetic function, unregulated microglia phagocytic activity and other related de-regulated biological functions. This invention further relates to methods and compositions for treating such neurodegenerative...

Published: 9/24/2024 | Inventor(s): Wei Wang, Rui Chang, Vijayan Ramachandran, Patrick Ronaldson

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Biologics

Off-Label Use of an Anti-Hypertensive to Treat Epilepsy

This is an already existing pharmaceutical called Candesartan that acts as an angiotensin II receptor blocker (ARB). This drug, from the class of sartan drugs, is typically used to treat hypertension and heart failure. However, University of Arizona researchers found it to be effective to reduce epileptic activity in a mouse model because it offers...

Published: 9/16/2024 | Inventor(s): Michael Hammer, Erfan Bahramnejad

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Therapeutics

Myelin Breakdown Products as Plasma Biomarkers of Therapeutic Efficacy in the Acute Phase after Stroke

This invention pertains to the use of myelin breakdown products, such as lipids indicative of brain lipid catabolism, as plasma biomarkers for the diagnosis and prognosis of ischemic stroke (IS). Researchers discovered an acute signature of brain lipid catabolism in the plasma 24 hours after a stroke in mouse model research. Notably, a substantial proportion...

Published: 8/12/2024 | Inventor(s): Kristian Doyle, Danielle Becktel

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Biomarkers

Arachidonic Acid Derivatives as Plasma Biomarkers of Chronic Inflammation After Stroke

This invention pertains to the use of arachidonic acid derivatives as plasma indicators for the diagnosis and prognosis of inflammation, including chronic inflammation, following ischemic stroke (IS). Researchers have identified novel plasma biomarkers indicative of neurodegeneration and inflammation in a mouse model of stroke, with particular emphasis...

Published: 8/12/2024 | Inventor(s): Kristian Doyle, Danielle Becktel

Keywords(s):

Diagnostic Tool for Identifying Delirium using Electronic Medical Records

Neurologic, Orientation and Verbal Assessment of Delirium (NOVAD) is a smart-EMR screening tool designed to detect delirium in hospitalized adults. NOVAD leverages assessments that nurses are already familiar with to provide an early warning system for delirium detection, empowering healthcare professionals with actionable insights, leading to timely...

Published: 7/10/2024 | Inventor(s): Nimit Agarwal, Sumit Agarwal

Keywords(s):

Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Medical Devices > Diagnostic

Novel, Humanized Transgenic Background Mouse Strain for Neurodegenerative Disease Research

This invention is a transgenic mouse model for the study of neurodegenerative diseases like Alzheimer’s and Parkinson’s Disease. This new model crosses a humanized APOE mouse model with a humanized APP gene, both common implicated genetic factors in Alzheimer’s Disease. The technology also developed a Parkinson’s Disease specific...

Published: 6/25/2024 | Inventor(s): Roberta Brinton, Jean Paul Wiegand, Lisa Campbell

Keywords(s):

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Healthcare Portfolios > Neurology

Stroke Outcome Prediction Using Vascular Imaging Features and Machine Learning

This technology is a stroke outcome prediction method to determine patient outcomes and inform treatment decisions. The method utilizes machine learning models trained with patient-specific vascular imaging features, patient demographics, stroke severity scores and clinical history as predictors to forecast a 90-day functional outcome following an ischemic...

Published: 8/1/2024 | Inventor(s): Aditi Deshpande, Kaveh Laksari, Jordan Elliott, Pouya Tahsili-Fahadan

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences

Rotational Force-Induced Brain Injury Model

This innovation is a new instrument, model, and treatment for repetitive rotational head trauma in rodents that demonstrates the acute and prolonged pathological, behavioral, and electrophysiological effects of rotational traumatic brain injury (rTBI). Aberrant Cyclin-dependent kinase 5 (Cdk5) activity is a principal mediator of rTBI. Cdk5-enriched...

Published: 6/20/2024 | Inventor(s): James Bibb, Alan Umfress

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Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Research Tools > Simulators and Modeling Tools, Technology Classifications > Life Sciences > Therapeutics

Natural Compounds including Myrosinase to Treat Alzheimer's Diseases

This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease. The inventors have applied computational approaches to existing rich data sets generated by the Accelerating Medical Partnership-Alzheimer's disease consortia to discover novel targets. There are natural compounds which have shown...

Published: 7/6/2023 | Inventor(s): Rui Chang

Keywords(s):

Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Healthcare Portfolios > Neurology

Druggable Formulation for Mu/Delta Opioid Antagonist for Enhancing Pain Therapy and Treatment of Opioid Withdrawal

This invention provides compositions and method of pain treatment using a mu/delta opioid receptor heterodimer (MDOR) antagonist which has improved druggability by nanoformulation and/or glycosylation to increase their bioavailability and efficacy. These modified antagonists and formulations provide for enhancement of opioid agonist therapy's antinociceptive...

Published: 3/12/2024 | Inventor(s): John Streicher, Robin Polt, Lajos Szabo, Wafaa Alabsi, Parthasaradhi Reddy Tanguturi

Keywords(s):

Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Neurology

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