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Organ-on-Chip Apparatus for Studying and Monitoring Acoustic Wave Interaction with Gas Bubbles and Disruption of Cellular Barriers
This invention relates to an ultrasound-transparent organ-on-chip platform and a method to study and monitor acoustic wave interaction with gas bubbles and disruption of cellular barriers. The invention can be used for drug screening for ultrasound gas bubble disruption of the blood-brain-barrier (BBB) for brain drug delivery and can be used as a product...
Published: 3/9/2026   |   Inventor(s): Jian Gu, Nabhan Fakrudin
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Research Tools > Simulators and Modeling Tools, Technology Classifications > Research Tools > Screening assays
Combining Plasmonic Nanostructures and Machine Learning to Detect and Modulate Protein Aggregation
This innovation is a nanotechnology- and artificial intelligence-powered platform that combines plasmonic gold nanomaterials (AuNMs) with machine learning (ML) to achieve high-throughput, selective, and broad-spectrum identification of potential inhibitors of amyloid beta aggregation. Proof of concept testing found that the platform can identify spectral...
Published: 3/2/2026   |   Inventor(s): Kenry FNU, Célia Sahli
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Research Tools > Simulators and Modeling Tools, Technology Classifications > Software & Information Technology > Health IT
Analytical Technology for the Isolation of 3-Nitrotyrosine as a Biomarker from Urine to Assess Depression and Acute Kidney Injury
This invention uses a novel separation technique to isolate specific biomarkers from urine, as a measure to detect and monitor depression and acute kidney injury (AKI). The system employs a hybrid chromatographic matrix that rejects biomolecules of specific sizes and allows only the desired small compounds, such as 3-nitrotyrosine (which has been linked...
Published: 1/6/2026   |   Inventor(s): Roberto Guzman, David Mier-Salazar
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Nephrology/Renal, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Medical Devices > Diagnostic
Novel Mechanism-Based Therapy for Aortic Stiffening and Related Cardiovascular and Cerebrovascular Disorders
This invention involves a novel mechanism-based therapy by using a small molecule compound to reduce aging and hypertensive aortic stiffening, subsequently improve blood pressure (BP) control in resistant hypertension patients and prevent or reverse pathologies of vascular cognitive impairment and dementia (VCID) and Alzheimer’s Disease (AD)....
Published: 11/24/2025   |   Inventor(s): Hongyu Qiu
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics
TDP-43 In Vivo Mouse Model
This is an in vivo mouse model of TDP-43 proteinopathy that captures key features of human neurodegenerative disease, particularly Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). The model targets a disease-relevant disruption in TDP-43’s interaction with cytoplasmic translational machinery, causing a cascade...
Published: 9/2/2025   |   Inventor(s): Xinglong Wang, Ju Gao
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Research Tools > Animal Models
Reflex-o-Meter
The Reflex-o-Meter is a novel system designed to support clinical training, telemedicine, and future robotic healthcare applications by quantifying deep tendon reflexes (DTRs). It integrates miniature motion sensors into a standard reflex hammer and pairs them with sensors placed on a patient's limb to record and transmit reflex response data. The...
Published: 6/26/2025   |   Inventor(s): Ramesh Karra, Kevin Kasper
Keywords(s):  
Category(s): Technology Classifications > Engineering & Physical Sciences > Devices & Instrumentation, Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Health Education, Medical Training and Operations, Technology Classifications > Healthcare Portfolios > Physical Medicine & Rehabilitation, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Sensors & Controls > Motion & Force
Using Audible EEGs for Assisting in Brain Disease Diagnosis
This technology makes electroencephalogram (EEG) recordings audible to hear differences in real time by putting the filtered waves through an algorithm. This allows specialists to better identify where brain activity is different in real time rather than through visual analysis, which may take longer and may be harder to capture. Background: Currently,...
Published: 5/28/2025   |   Inventor(s): Tally Milnes, Matthew Flowers, Cynthia Stokes, Michael Vince
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Creative Works & Copyright
Hearing the Invisible
This is an immersive art experience in which individuals will walk through a model of a brain while using augmented reality (AR) for a more realistic, immersive experience. Attendees also listen to sonified electroencephalograms (EEGs) of healthy brains and brains with different diseases, such as dementia and Alzheimer’s which allows them to hear...
Published: 4/17/2025   |   Inventor(s): Tally Milnes, Cynthia Stokes, Michael Vince, Matthew Flowers, Brian McElroy
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Creative Works & Copyright
Augmented Reality App for Audible EEG
This is an augmented reality app for use with the Hearing the Invisible immersive experience in which attendees listen to audio versions of electroencephalograms (EEGs) to hear the difference between healthy brains and brains with different diseases, such as dementia and Alzheimer’s. QR codes throughout the experience link to the app, which has...
Published: 4/17/2025   |   Inventor(s): Tally Milnes, Michael Vince, Brian McElroy, Cynthia Stokes, Matthew Flowers
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Software & Information Technology > Mobile Application, Technology Classifications > Creative Works & Copyright
Hearing the Invisible Original Composition
This is a live performance of an original composition created for the Hearing the Invisible immersive art experience using electroencephalograms (EEGs) as a base for the audio. It includes original vocal and electronic musical composition. Background: Music and/or other audio sounds can augment immersive art experiences. They can be original compositions,...
Published: 4/17/2025   |   Inventor(s): Tally Milnes, Michael Vince, Cynthia Stokes, Matthew Flowers
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Creative Works & Copyright
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