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Chimetic Antigen Receptor (CAR)-Stem Cells (MSCs) and its use for Cardiovascular Diseases
This technology describes Chimetic Antigen Receptor (CAR) mesenchymal stem cells (MSCs) and their use in treatment of cardiovascular diseases. This technology will use engineered MSCs capable of homing toward infarcted heart tissue. Background: Cardiovascular disease is the leading cause of death in the United States. There are multiple treatments...
Published: 1/7/2025   |   Inventor(s): Youngwook Won, Byeong Hyun Cha, David Bull
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Stem Cells, Technology Classifications > Life Sciences > Therapeutics
Custom Coded Raspberry Pi Pico to Induce Atrial Fibrillation in Swine
This invention is a low cost, reproduceable device designed to reproduce atrial fibrillation (AFib) in swine to create a large animal model of persistent AFib. Using a Raspberry Pi Pico microcontroller to burst pace, this device allows for more modularity and can be programmed with many common programming languages. This large animal model can help...
Published: 12/16/2024   |   Inventor(s): Steven Goldman, Fox Bravo, Adrian Grijalva, Talal Moukabary, Alan Salciccioli
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology > Health IT, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Healthcare Portfolios > Heart and Vascular
Factor XII(a) is a Biotarget for Treatment of Dilated Cardiomyopathy and Heart Failure
Researchers at the University of Arizona have identified a novel, previously unrecognized harmful role of coagulation factor, Factor XII (FXII) and/or activated coagulation factor XIIa (fXII(a)) in modulating the progression of dilated cardiomyopathy and heart failure development. They have proposed fXII(a) as a new biotarget to treat dilated cardiomyopathy...
Published: 12/4/2024   |   Inventor(s): Guy Reed, Inna Gladysheva, Ryan Sullivan
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
Applications of Deuterated Aldehydes and Isonitriles
This innovation is a novel method of synthesizing calcium channel blockers, with applications to extend the half-life of heart disease medications. This can be used as building blocks to create new pharmaceuticals or potentially used to expand the lifespan of current medications. It has applications to site specific calcium-channel blocking that can...
Published: 6/7/2024   |   Inventor(s): Christopher Hulme, Wei Wang, Kevin Schofield, Yueteng Zhang
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
Time Resolved Fluorescence based HTS to Detect Structural Changes in cTnI
This innovation involves the development of a probe that attaches to a specific protein called cardiac troponin I (cTnI), which is involved in muscle contraction of the heart. This probe, created through genetic engineering techniques, is designed to detect changes in cTnI's neighboring protein, cardiac troponin T (cTnT). When there's a change...
Published: 5/13/2024   |   Inventor(s): Romi Castillo, Jil Tardiff
Keywords(s):  
Category(s): Technology Classifications > Research Tools, Technology Classifications > Sensors & Controls > Biologic, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
DeScoD-ECG: Deep Score-Based Diffusion Model for ECG Baseline Wander and Noise Removal
The DeScoD-ECG model is a novel electrocardiogram (ECG) baseline wander and noise removal technology that extends the current diffusion model for reconstructing electrocardiogram signals. It establishes a new benchmark in biomedical signal processing to provide a more accurate approximation of ECG signals for detection of cardiovascular irregularities....
Published: 8/23/2024   |   Inventor(s): Ao Li, Huayu Li, Gregory Ditzler, Janet Roveda
Keywords(s):  
Category(s): Technology Classifications > Software & Information Technology > Communications & Networking, Technology Classifications > Software & Information Technology > Open Source, Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Diagnostics
PNA5 Treatment in Myocardial Ischemic Reperfusion Injury Decreases Infarction Size and Promotes Heart Function
This innovation is a novel method of treating cardiovascular disease, specifically, the continued tissue damage that occurs during myocardial ischemic reperfusion injury (MIRI) elicited by myocardial ischemia. While damage during MIRI is multifaceted, this new treatment addresses nearly every caveat including reactive oxygen species (ROS), calcium overload,...
Published: 4/4/2024   |   Inventor(s): Meredith Hay, John Konhilas, Christina Hoyer-Kimura, Robin Polt
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
Methods of Treating Dilated Cardiomyopathy and Heart Failure
This innovation is the repurposing of drugs used for testosterone-suppression (androgen deprivation) as an innovative strategy to treat heart failure or dilated cardiomyopathy. These drugs are used for treatment of patients with advanced prostate cancer or for adolescents presenting with precocious puberty. This research is supported by published data...
Published: 7/1/2024   |   Inventor(s): Guy Reed, Inna Gladysheva, Ryan Sullivan
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Therapeutics
Polymeric Valve for Tricuspid Applications
This invention is a medical implant that is made of polymeric and metallic materials that functions as a replacement valve for tricuspid applications. The valve functions as a flow regulator and can be installed in low pressure, low flow and low shear cardiovascular structures. It is specifically engineered to reduce stress on the implant structure...
Published: 12/19/2024   |   Inventor(s): Marvin Slepian, Danny Bluestein, Brandon Kovarovic
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Heart and Vascular, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Medical Devices > Therapeutic
Heart Valve for Eccentric Orifice
This technology is a novel heart valve and deployment system that maintains eccentric geometries while optimizing valve function and hemodynamics, reducing adverse events. The asymmetrical leaflet design features two identical mirrored larger leaflets and one shorter leaflet. Traditional symmetric leaflet design features three equal leaflets that rely...
Published: 12/19/2024   |   Inventor(s): Marvin Slepian, Danny Bluestein, Brandon Kovarovic, Ryan Helbock
Keywords(s):  
Category(s): Technology Classifications > Medical Devices > Therapeutic, Technology Classifications > Healthcare Portfolios > Heart and Vascular
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