Search Results - technology+classifications+%3e+gene+therapy

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A New High-Throughput Cell Biology Method to Screen for Genes Critical for Cell Differentiation
A high-throughput method for identifying genes involved in the process of stem cell differentiation into specialized cells. Background: One of the many draws of stem cells is their potential for regenerating tissues, nerves, and other organs, but the differentiation potential of stem cells is highly regulated by genes. Therefore, the ability to...
Published: 7/11/2023   |   Inventor(s): Chunyu Liu
Keywords(s): cell culture, development, differentiation, high-throughput, neuroscience, regenerative medicine, screen
Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy
Generating Retinal Progenitors by Using the Two Required Transcription Factors
Use of transcription factors to promote and accelerate formation and maturation of retinal progenitors for ocular regenerative medicine. Background: Generation of autologous pluripotent-derived retinal progenitor cells represents a promising path for treating various disorders associated with vision impairment or blindness. However, the process can...
Published: 9/19/2024   |   Inventor(s): Andrea Viczian, Michael Zuber
Keywords(s):  
Category(s): Campus > Upstate Medical University, Technology Classifications > Gene Therapy, Technology Classifications > Healthcare
Gsx1 GENE THERAPY TO TREAT SPINAL CORD INJURY
​ Gsx1 treatment promotes recovery of locomotion function in injured mice. Invention Summary: Spinal cord injury (SCI) can lead to permanent disruption of nervous system function. There is no effective treatment for promoting recovery of motor function after SCI currently available on the market. Previous research on SCI treatment focused on...
Published: 6/12/2023   |   Inventor(s): Li Cai, Misaal Patel, Lisa Lyu
Keywords(s): Spinal Cord
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy, Technology Classifications > CNS Disorder
RNA-Aptamer-Mediated Base Editing System for Agriculture
­​ Invention Summary: The CRISPR/Cas system is a powerful tool for precision genetic engineering in organisms including plants. However, the conventional CRISPR technology depends on DSBs which may lead to undesired genetic events such as off-target insertions, deletions, and chromosomal translocations. The Base Editing technology...
Published: 4/21/2024   |   Inventor(s): Shengkan (Victor) Jin, Juan-Carlos Collantes
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics
Controlled Muscle-Specific Gene Delivery
​ ​ Treatment with the AAV gene therapy with doxycycline (B) induced expression of the target gene. Invention Summary: Adeno-associated virus (AAV) vector-based gene therapy has the potential to treat a number of rare diseases. However, only two AAV-based gene therapies have been approved by the FDA, primarily due to toxicity and lack of specificity. Researchers...
Published: 5/2/2024   |   Inventor(s): Renping Zhou
Keywords(s): Gene editing
Category(s): Technology Classifications > Gene Therapy, Technology Classifications > Healthcare & Life Sciences
RNA-Aptamer-Mediated Base Editing System
​ ​ Invention Summary: The CRISPR/Cas9 system is a powerful tool for targeted genetic engineering in organisms ranging from animals to plants. Cas9 has intrinsic nuclease activity, which causes sequence specific DNA double-strand breaks (DSBs), leading to activation of cellular pathways such as homology dependent repair (HDR) for gene conversion...
Published: 3/18/2024   |   Inventor(s): Shengkan (Victor) Jin, Juan-Carlos Collantes
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Research Tools, Technology Classifications > Gene Therapy
MicroRNA-7 Gene Therapy Promotes Functional Recovery Following Spinal Cord Injury
Following sever spinal cord compression, the AAV-miR-7 injected mice showed improved locomotor recovery, which is characterized by the Basso Mouse Scale (BMS). Invention Summary: Spinal cord injury (SCI) results in partial or complete loss of sensory or motor function. According to the National Spinal Cord Injury Statistical Center,...
Published: 4/21/2024   |   Inventor(s): M. Maral Mouradian, Eunsung Junn, Myung-Sik Yoo
Keywords(s): Spinal Cord
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy
A Chemogenetic Therapy for Neuropathic Pain
Invention Summary: Neuropathic pain (NP) typically arises as a consequence of a lesion or disease affecting peripheral nerve fibers. Prominent features in the pathophysiology of neuropathic pain include increased, ectopic neuronal activity in pain pathways. In general, NP is frequently refractory to conventional analgesics and currently there are...
Published: 11/7/2022   |   Inventor(s): Gary Aston-Jones
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics, Technology Classifications > Gene Therapy
dCas9 Protein Allele Sequestration for Improved CRISPR Gene Editing
>​ Invention Summary: CRISPR technology is widely used in research to edit genes in animals and cell lines and is moving towards therapeutic use in the clinic. Inherent to almost all methods employed in gene editing is the lack of control in target gene usage. A method to direct cleavage of only a single target within a cell would be beneficial...
Published: 5/14/2024   |   Inventor(s): Peter Romanienko, Ghassan Yehia
Keywords(s): Gene editing
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Gene Therapy, Technology Classifications > Research Tools
Novel Gene Therapy to Treat L-DOPA-Induced Dyskinesia
Viral vector injections of rAAV-∆FosB shRNA significantly reduced abnormal involuntary movements (AIMs) compared to control vector in a rat model of Parkinson’s disease. Invention Summary: Parkinson's disease (PD) is a progressive, debilitating, and currently incurable neurodegenerative disease. Long-term dopamine replacement therapy in...
Published: 2/21/2022   |   Inventor(s): Mary Maral Mouradian, Stella Papa
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Gene Therapy, Technology Classifications > Therapeutics
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