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Tiny “Light-Twisting” Lasers For Faster, More Secure Encryption Keys
Quantum on-chip device that powers future ultra-secure, high-speed digital communication by encoding more information into single particles of light. Problem: Quantum key distribution (QKD) is a new way to create secure communication systems; however, it is limited to sending only a small amount of information at a time. Most current systems use qubits,...
Published: 2/8/2026   |   Inventor(s): Liang Feng, Yichi Zhang
Keywords(s): Electronic Materials
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Hardware & Components
Instant, Calibration-Free Blood-Flow Measurement With A Single Optical Snapshot
A single-frame, multi-exposure time optical method enabling accurate extraction of absolute speckle decorrelation time and optimized for recovery of absolute deep-tissue blood flow. Problem: Accurately recovering absolute speckle decorrelation time without the use of calibration or complex instrumentation is challenging. For the use case of monitoring...
Published: 1/8/2026   |   Inventor(s): Arjun Yodh, Wesley Baker, Joseph Majeski, Rodrigo Menezes Forti
Keywords(s): Bioengineering, Cardiovascular, Electronic Materials, Gastroenterology, Internet of Things, Nephrology and Urology, Neurology, Oncology, Ophthalmology, Optics & Photonics , Platform Technology, Surgery
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Diagnostics, Technology Classifications > Digital Health, Technology Classifications > Hardware & Components, Technology Classifications > Imaging, Technology Classifications > Research Tools & Reagents, Technology Classifications > Medical Devices, Technology Classifications > Testing & Measurement
Commercially Scalable Quantum Internet Architecture
A hybrid photonic system that enables quantum networking to scale across existing fiber infrastructure. Problem: Developing a commercially scalable quantum internet—one that can substantially reduce deployment costs by using existing fiber networks—is challenged by the fact that current quantum systems remain isolated laboratory platforms...
Published: 1/13/2026   |   Inventor(s): Liang Feng, Yichi Zhang, Robert Broberg, Jonathan Smith
Keywords(s): Electronic Materials, Optical/Photonic Architecture, Optics & Photonics 
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Hardware & Components, Technology Classifications > Materials
Electronic-Photonic Quadrature Delay-Locked Oscillator (DLO) For Efficient High-Speed Clock Generation And Distribution
A Quadrature Delay-Locked Oscillator that caters to increasing multi-GHz and multi-phase clock demands in systems such as time-interleaved architectures. Problem: The unrelenting growth of artificial intelligence (AI) requires advancements in high-performance hardware capable of delivering high-speed clock generation and distribution. These improvements...
Published: 10/29/2025   |   Inventor(s): Firooz Aflatouni, Henry Love
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Electronic Materials, Optics & Photonics 
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Hardware & Components
SMOOTHLLM: Defending Large Language Models Against Jailbreaking Attacks
An algorithm designed to defend Large Language Models (LLMs) against jailbreaking attacks that significantly reduces attack success rates. Problem: Despite efforts to align LLM outputs with ethical standards, the models exhibit persistent weaknesses against adversarial attacks that bypass alignment mechanisms and safety guardrails, commonly known as...
Published: 8/21/2025   |   Inventor(s): George Pappas, Alexander Beck Robey, Seyed Hamed Hassani, Eric Wong
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Software
Category(s): Technology Classifications > Business Ideas, Technology Classifications > Computer Information Systems
NetSpec: An Automatic And Fast Network Specification Synthesis Toolkit
A specification-by-example toolkit that generates formal network specifications using only input-output examples. Problem: Many modern computer systems run on networks like cloud clusters or distributed systems. However, the network protocols that support the operation and security of these systems are notoriously difficult to debug. Formal network...
Published: 11/19/2024   |   Inventor(s): Boon Loo, Haoxian Chen, Mayur Naik, Chenyuan Wu, Mukund Raghothaman
Keywords(s): Software
Category(s): Technology Classifications > Computer Information Systems
Physical Neural Network for Fast, Scalable, and Power-Efficient Machine Learning Computation
A physical embodiment of a locally-learning neural network, which learns faster than current CPU-based nets. Problem: Machine learning is a ubiquitous tool that has found uses in engineering, science, and medicine. Neural networks are some of the most powerful machine learning algorithms, but they train very slowly when they become large. This hampers...
Published: 9/26/2025   |   Inventor(s): Samuel Dillavou, Douglas Durian, Andrea Liu, Menachem (Nachi) Stern, Marc Miskin
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Data Science, Electronic Materials, Internet of Things, Nanotechnology, Software
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Hardware & Components
PanoRadar: A High Resolution, Radio Frequency-Based 3D Imaging System
A radio frequency-based 3D imaging system that can generate LiDAR-comparable images with reduced power and processing needs. Problem: With the emergence of robotic and autonomous systems in areas such as transportation, search and rescue, construction, healthcare assistance, and warehouse management, radio frequency (RF) signal-based sensing and imaging...
Published: 1/8/2026   |   Inventor(s): Mingmin Zhao, Gaoxiang Luo, Yifei Li, Haowen Lai
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Autonomous Vehicles, Imaging Agents
Category(s): Technology Classifications > Computer Information Systems, Technology Classifications > Hardware & Components, Technology Classifications > Imaging
SCALPEL or Secure Compartments Automatically Learned and Protected by Execution Using Lightweight Metadata
SCALPEL is a lightweight optimization tool for automatically compartmentalizing policies for hardware-accelerated enforcement in a tagged architecture. The tool also creates a layer or protection (or hardening) by learning and allowing certain privileges based on learned expectations. Problem: The languages of operating systems, device drivers and embedded...
Published: 9/26/2025   |   Inventor(s): Andre DeHon, Nicholas Roessler
Keywords(s): Artificial Intelligence (AI) & Machine Learning, Internet of Things, Software
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Computer Information Systems
Virtual QA with High Predicted Accuracy for IMRT Treatment Plans
The course of radiation treatment of cancer patients has three major phases: Diagnostic and Prescription; Simulation and Quality Assurance; and Delivery. In Simulation and Quality Assurance (QA), a specific plan on how to deliver the prescribed radiation to the tumor is developed. Penn scientists have developed a software-based virtual Intensity...
Published: 4/25/2025   |   Inventor(s): Gilmer Valdes, Timothy Solberg
Keywords(s):  
Category(s): Technology Classifications > Computer Information Systems
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