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­SELECTIVE SENSITIZATION OF CANCER CELLS TO ELIMINATION BY CYTOTOXIC LYMPHOCYTES
­SELECTIVE SENSITIZATION OF CANCER CELLS TO ELIMINATION BY CYTOTOXIC LYMPHOCYTES Researchers at Stanford University have developed a novel method for the treatment and prevention of cancer. The immune system is an integral part of the human body’s response to outside threats, including cancer. Specifically, cytotoxic CD8+ T cells have been...
Published: 9/24/2024   |   Inventor(s): Reece Akana
Keywords(s): Cancer, Immuno-Oncology, T-Cell Activation
Category(s): Technology Classifications > Biology
­COMPOSITIONS AND METHODS FOR RE-ACTIVATION OF DYSFUNCTIONAL SKELETAL STEM CELLS
­COMPOSITIONS AND METHODS FOR RE-ACTIVATION OF DYSFUNCTIONAL SKELETAL STEM CELLS Researchers at Stanford University have developed a novel therapeutic avenue for the treatment of osteoporosis and other musculoskeletal diseases. Musculoskeletal disease incidence rates have increased in recent years in response to an aging population. Available...
Published: 9/24/2024   |   Inventor(s): Charles Chan, Thomas Ambrosi, Irving Weissman, Michael Longaker, Rahul Sinha, Debashis Sahoo
Keywords(s): Hydrogel, Stem Cell
Category(s): Technology Classifications > Biology
DESIGN OF UNIVERSAL H5 INFLUENZA VIRUS VACCINE CANDIDATES VIA ANTIGEN REORIENTATION
­DESIGN OF UNIVERSAL H5 INFLUENZA VIRUS VACCINE CANDIDATES VIA ANTIGEN REORIENTATION Researchers at Stanford University have developed novel universal vaccine candidates for H5 influenza viruses. Influenza remains a serious threat to public health. H5 avian influenza strains are among the most concerning despite lack of documented human to human...
Published: 9/24/2024   |   Inventor(s): Duo Xu, Peter Kim
Keywords(s): Immunofocusing, Vaccine
Category(s): Technology Classifications > Biology
­DIALYSIS-BASED METHOD FOR AFFINITY MAPPING OF CHROMATIN INTERACTION
­DIALYSIS-BASED METHOD FOR AFFINITY MAPPING OF CHROMATIN INTERACTIONS Researchers at Stanford have developed methods for preparing chromatin from cells for downstream genomic chromatin mapping. Chromatin profiling strategies are widely used to map the genomic location of chromatin elements, such as histone post-translational modification and...
Published: 6/6/2024   |   Inventor(s): Nicolas Altemose, Aaron Straight, Kousik Sundararajan, Nathan Gamarra
Keywords(s): Chromatin, Genomic, Mapping, Nuclear
Category(s): Technology Classifications > Biology
­HYDROGEL-ECM GRANULAR COMPOSITES WITH VISCOUS INTERSTITIUM
­HYDROGEL-ECM GRANULAR COMPOSITES WITH VISCOUS INTERSTITIUM Researchers at UCSF and CZ Biohub San Francisco have developed methods for making and using yield-stress composite matrix formulations for organoid printing. Organoids are attractive models of health and disease as they recapture many important structural and physiological aspects of...
Published: 6/6/2024   |   Inventor(s): Austin Graham, Zev Gartner, Rafael Gomez-Sjoberg
Keywords(s): Bioprinting, Organoid
Category(s): Technology Classifications > Biology
­HIGH THROUGHPUT METHOD FOR SCREENING LIPID NANOPARTICLE EFFICACY AND CYTOTOXICITY
­HIGH THROUGHPUT METHOD FOR SCREENING LIPID NANOPARTICLE EFFICACY AND CYTOTOXICITY Researchers at Berkeley have developed synthetic cell membranes that are optimized for screening the toxicity and efficacy of lipid nanoparticle formulations in vitro, in a high throughput format. Lipid nanoparticles (LNPs) represent a highly effective and efficient...
Published: 4/22/2024   |   Inventor(s): Markita Landry, Alison Lui
Keywords(s): Nanoparticle, SARS-CoV-2, Vaccine
Category(s): Technology Classifications > Biology
METHODS AND COMPOSITION FOR TARGETED RECEPTOR-MEDIATED PROGRAMMABLE MACROMOLECULE DELIVERY
­METHODS AND COMPOSITION FOR TARGETED RECEPTOR-MEDIATED PROGRAMMABLE MACROMOLECULE DELIVERY Researchers at Stanford have developed a novel method for programmable macromolecule delivery via engineered cells, using trogocytosis. Genome editing technologies have revolutionized the field of personalized medicine. Despite its initial promise, many...
Published: 4/22/2024   |   Inventor(s): Lei Qi, Xinyi Chen, Wendy Fantl
Keywords(s): Fusion Protein, Protein Engineering, Trogocytosis
Category(s): Technology Classifications > Biology
­NON-INVASIVE PROFILING OF URINARY TRACT TISSUES WITH URINE LIQUID BIOPSY
­NON-INVASIVE PROFILING OF URINARY TRACT TISSUES WITH URINE LIQUID BIOPSY Researchers at Stanford and UCSFhave determined methods of performing cell-free RNA (cfRNA) transcriptomics and metabolomics on urine samples. Urine is assayed alongside blood in medicine, however current clinical diagnostic tests exploit only a minor fraction of its biomolecular...
Published: 2/14/2024   |   Inventor(s): Sevahn Vorperian, Stephen Quake, Gabriel Loeb
Keywords(s): Biopsy, cfRNA, Liquid, Urine
Category(s): Technology Classifications > Biology
­GENERATION OF ANTIGEN-SPECIFIC T AND B CELLS USING ENGINEERED COMMENSALS
­GENERATION OF ANTIGEN-SPECIFIC T AND B CELLS USING ENGINEERED COMMENSALS Researchers at Stanford have developed methods to link antigenic or immunomodulatory molecules to bacterial surface proteins of commensal bacteria that result in a high immune response when applied to an epithelial surface of a mammal. Commensal microbiota reside primarily...
Published: 2/14/2024   |   Inventor(s): Michael Fischbach, Djenet Bousbaine, Christopher Barnes, Katherine Bauman, Yasmine Belkaid
Keywords(s): Antigen, Bacteria, Immunomodulator
Category(s): Technology Classifications > Biology
­CELL-PENETRATING PEPTIDES FOR NUCLEIC ACID AND PROTEIN DELIVERY IN PLANTS
­CELL-PENETRATING PEPTIDES FOR NUCLEIC ACID AND PROTEIN DELIVERY IN PLANTS Researchers at UC Berkeley have developed methods to deliver biomolecules to plant cells using new plant-derived cell penetrating peptides (CPPs). Despite the revolution in DNA editing that the last decade has brought, plant genetic engineering has not been able to benefit...
Published: 2/14/2024   |   Inventor(s): Markita Landry, Jeffrey Wang, Henry Squire
Keywords(s): Cell Wall, Delivery Method, Plant
Category(s): Technology Classifications > Biology
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