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Enhancing Drug Bioavailability: Curcumin and Its Derivatives as Modulators of UGT2B17 and Intestinal Enzymes

Unmet Need: Inhibitor drugs of UGT2B17 that can be used for boosting bioavailability of its substrates. Since curcumin is a safe bioactive compound with potential health benefits, however, it has poor bioavailability, inventors have explored the use of curcumin as a bioavailability enhancer of other nutrients or drugs. They have developed an approach...

Published: 10/8/2024 | Inventor(s): Bhagwat Prasad, Deepak Ahire, Siavosh Naji-Talakar, Dilip Kumar Singh, Namrata Bachhav

Keywords(s): Bioavailability booster, Curcumin, Intestinal metabolism, UGT2B17

Category(s): Technologies > Health & Well-being > Biotechnology, Technologies > Health & Well-being > Pharmaceutical, Technologies > Health & Well-being > Global Human and Animal Health

Mice with humanized telomere homeostasis

Unmet Need: The imperative need for mouse models in advancing research on human aging and tumorigenesis Telomeres play a key role in human aging and tumorigenesis. However, studying telomeres in mouse models presents challenges due to significant difference in telomere length, which is up to 10 times longer than in humans. To address this limitation,...

Published: 10/8/2024 | Inventor(s): Jiyue Zhu, Shuwen Wang, Fan Zhang, De Cheng

Keywords(s): Animal Research, Biotechnology, Cancer and aging, Genome editing, Human Research, Male Infertility, Telomere and telomerase

Category(s): Technologies > Health & Well-being > Biotechnology

Scalable manufacturing of flexible electronics via screen printing for biomedical applications

Unmet Need: Flexible and stretchable electrodes face challenges in commercial adoption due to complex and costly microfabrication processes Current manufacturing processes for flexible biomedical electronics are complex and expensive, typically requiring cleanroom microfabrication. While other methods have been explored, none cover the full fabrication...

Published: 10/8/2024 | Inventor(s): Jong Kim

Keywords(s):

Category(s): Technologies > Health & Well-being > Biotechnology

Foldable Polymers as Gene Probes

Abstract This technology utilizes novel probes to detect and identify target biomolecules in a sample. These probes employ conformational changes induced by molecular recognition events to initiate changes in the optical properties of the probe (e.g. the modulation of a fluorescence or absorption response upon target binding). Methods, including solid...

Published: 10/8/2024 | Inventor(s): Alexander Li, Wei Wang

Keywords(s): Advanced Materials, Biotechnology

Category(s): Technologies > Next Generation Materials & Technology > Advanced Materials, Technologies > Health & Well-being > Biotechnology

Wheat Variety 'Otto' (WA8092), Soft White Winter Wheat

Otto, is a soft white common wheat developed and released in 2011 by the Agricultural Research Center of Washington State University. Otto was named in honor of Otto Amen, a former state representative, WSU alumnus, and wheat producer who established an endowment to fund dryland wheat research in Washington.Otto provides a combination of excellent yield...

Published: 10/8/2024 | Inventor(s): Arron Carter, Stephen Jones

Keywords(s):

Category(s): Technologies > Food & Nutrition > Agriculture and Plant Sciences, Technologies > Food & Nutrition > Cereal Varieties, Technologies > Health & Well-being > Biotechnology

Rapid Electrochemical Assay for Detecting Antibiotic Susceptibility (READAS)

Unmet Need: Fast and effective technique to expedite antibiotic selection Studies show that each year in the U.S., at least 2.8 million people are infected with antibiotic-resistant bacteria or fungi, and more than 35,000 people die as a result. According to the World Health Organization’s 2016 report, the number of drug-resistant infections...

Published: 10/8/2024 | Inventor(s): Douglas Call, Haluk Beyenal, Abdelrhman Mohamed, Gretchen Tibbits

Keywords(s): Antimicrobial Resistance, Clinical microbiology

Category(s): Technologies > Health & Well-being > Biotechnology, Technologies > Health & Well-being > Medical Devices, Technologies > Health & Well-being > Global Human and Animal Health

Germline Ablation in Goats

Unmet Need: Accurate and dependable breeding of desired traits While livestock all over the world exhibit a variety of traits that allow them to survive in different environments, they don’t always have other qualities breeders deem to be desirable, like high quality meat or growth potential. In the past, people would bring in a male –...

Published: 10/8/2024 | Inventor(s): Jon Oatley, Irina Polejaeva

Keywords(s): Agriculture, Animal Research, Genome editing, Germline Ablation, Nanos2, Sperm, Spermatgonial stem cell

Category(s): Products, Technologies > Health & Well-being > Biotechnology, Technologies > Health & Well-being > Veterinary, Technologies > Food & Nutrition > Agriculture and Plant Sciences

A NATURAL ANTIMICROBIAL TO CONTROL PATHOGENIC E. COLI

AbstractHarmful strains of Escherichia coli bacteria, primarily found in cattle cause severe, sometimes life-threatening human illness. According to the US Centers for Disease Control and Prevention, an estimated 110,000 cases (due to specifically enterohaemorrhagic E. coli (EHEC)) occur annually in the United States, and is now plaguing more than 30...

Published: 10/8/2024 | Inventor(s): Douglas Call, Lauren Eberhart, Kelly Brayton, Thomas Besser, Ashish Sawant, Lisa Orfe

Keywords(s): Biotechnology, Veterinary

Category(s): Technologies > Health & Well-being > Biotechnology, Technologies > Health & Well-being > Global Human and Animal Health, Technologies > Health & Well-being > Veterinary

TFAM Gene Markers Marbling and Backfat in Beef Cattle

Significant improvements in animal performance, efficiency and carcass and meat quality have been made over the years through the application of standard animal breeding and selection techniques. However, such classical animal breeding techniques require several years of genetic evaluation of performance records on individual animals and their relatives...

Published: 10/8/2024 | Inventor(s): Zhihua Jiang, Tanja Kunej

Keywords(s):

Category(s): Technologies > Food & Nutrition > Food Science and Nutrition, Technologies > Health & Well-being > Biotechnology

FABP4 Gene Markers for Marbling and Backfat in Beef Cattle

Abstract Significant improvements in animal performance, efficiency and carcass and meat quality have been made over the years through the application of standard animal breeding and selection techniques. However, such classical animal breeding techniques require several years of genetic evaluation of performance records on individual animals and their...

Published: 10/8/2024 | Inventor(s): Zhihua Jiang, Jennifer Michal

Keywords(s):

Category(s): Technologies > Food & Nutrition > Food Science and Nutrition, Technologies > Health & Well-being > Biotechnology

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