Search Results - simon+d%e2%80%99oelsnitz

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Engineered methyltransferase for microbial production of the Alzheimer’s drug galantamine
­Problem Galantamine is a cholinesterase-inhibiting compound used for the treatment of cognitive decline in mild to moderate cases of Alzheimer’s disease and other memory impairment disorders. Galantamine is a plant alkaloid found in the bulbs and flowers of several species including daffodils, snowdrops, and red spider lilies. Galantamine...
Published: 4/18/2024   |   Inventor(s): Andrew Ellington, Simon d’Oelsnitz, Daniel Diaz
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Research tools > Reagent
An engineered methyltransferase enzyme for improved production of benzylisoquinoline alkaloids
Background Tetrahydropapaverine (THP) and papaverine are naturally occurring plant alkaloids that are commercially important. THP is a precursor of the drugs atracurium and cisatracurium, used as muscle relaxants. Papaverine is used as an antispasmodic. These clinically useful molecules may be synthesized using traditional organic synthesis methods...
Published: 11/27/2023   |   Inventor(s): Andrew Ellington, Simon d’Oelsnitz, Mohammad Javanmardi, Ross Thyer
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent, Life sciences > Diagnostic