Search Results - shar-yin+huang

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Topoisomerase III (TOP3) Inhibitors as Antiviral and Anticancer Compounds based on Bisacridines
Abstract: Topoisomerase 3B (TOP3B) is the only topoisomerase that can act on RNA as well as DNA. Thus, it is a target of interest for the development of cancer therapies and RNA viral infection therapies. TOP3B is not an essential gene for carcinogenesis, but a subset of cancer cells with pre-existing genome instability are particularly vulnerable to...
Published: 4/8/2024   |   Inventor(s): Yves Pommier, Sourav Saha, Wenjie Wang, Shar-yin Huang
Keywords(s): Bisacridines, CANCER, Pommier, SARS-CoV-2, TOP, TOP3, TOP3 Inhibitor, TOPOISOMERASE, Topoisomerase III, Topoisomerase Inhibitor, viral infection
Category(s): TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Oncology
Synergistic Use of Exo VII Inhibitors And Quinolone Antibiotics For Treating Bacterial Infection
Abstract: Topoisomerase poisons, such as quinolone antibiotics, are widely used as anticancer drugs and antibiotics. Quinolone antibiotics act by trapping prokaryotic type IIA topoisomerases (DNA gyrase and TOPO IV), resulting in irreversible topoisomerase cleavage complexes. However, current U.S. Food and Drug Administration (FDA) guidance reserves...
Published: 4/8/2024   |   Inventor(s): Yves Pommier, Shar-yin Huang, Brianna Mitchell
Keywords(s): Antibacterial, Antibiotic Adjuvants, Antibiotic Resistance, DNA gyrase, Exonuclease VII, ExoVII, Infection, Pommier, Quinolone, TOPO IV, Topoisomerase Poisons
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Application > Therapeutics
Topoisomerase III (TOP3) Inhibitors and Antiviral Compounds based on Cyanine Dyes
Topoisomerase 3B (TOP3B) is the only topoisomerase that can act on RNA as well as DNA, and thus has been a target of interest for the development of cancer therapies and RNA viral infection therapies. In the context of cancer, TOP3B is not an essential gene, but a subset of cancer cells with pre-existing genome instability are particularly vulnerable...
Published: 4/8/2024   |   Inventor(s): Yves Pommier, Shar-yin Huang, Wenjie Wang, Weidong Wang, Sourav Saha, Tianyi Zhang, Mariano Garcia-Blanco, Pei-Yong Shi, Yuk-Ching Tse-Dinh, Debbie Kennedy-Boone
Keywords(s): CANCER, Cyanine Dye, NIA, Pommier, SARS-CoV-2, TOP, TOP3, TOP3 Inhibitor, TOPOISOMERASE, Topoisomerase III, Topoisomerase Inhibitor, viral infection, Wang
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology
Processing Technique for Ceramic- based Energy Conversion and Storage Devices
Due to rising carbon emissions, extreme weather events and other environmental threats, the demand for alternative energy sources is greater than ever. Therefore, businesses and communities are asking for three things: more affordable electricity, more resilient power, and cleaner energy. Fuel cells, electrolysis cells, membrane reactors, and solid-state...
Published: 1/11/2024   |   Inventor(s): Hai Xiao, Jianhua Tong, Fei Peng, Kyle Brinkman, Jincheng Lei, Yuzhe Hong, Hua Huang, Shenglong Mu, Rajendra Bordia
Keywords(s):  
Category(s): Manufacturing
Automated Pain Detection in Pediatric Care
uot;Times New Roman",serif; font-size:12pt">Unmet Need: Continuous pain assessment in infants Continuing advances in intensive care have made it possible for premature infants to survive outside the uterus in Neonatal Intensive Care Unit (NICU) even at very early stages of development. Infants in the NICU may receive an estimated 10-14 painful...
Published: 6/27/2022   |   Inventor(s): Subhanshu Gupta, Huan Hu, Martin Schiavenato
Keywords(s):  
Category(s): Technologies > Health & Well-being > Health-IT, Technologies > Health & Well-being > Medical Devices, Technologies > Energy & Environment > Computer Hardware/Software, Technologies > Energy & Environment > Electrical/Electronics