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Method for Treating Acute Kidney Injury
This invention is based, at least in part, on the discovery that kidney injury results in an up-regulation of Wnt ligands in macrophages and the canonical Wnt response in epithelial cells. While macrophages from the injured kidney are a source of increased Wnt activity, compromise of Wnt receptors or conditional deletion of Wnt7b in the macrophage lineage...
Published: 8/15/2024   |   Inventor(s): Richard Lang, Jeremy Duffield
Keywords(s): 1 - Therapeutic
Category(s): Therapeutics