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Mouse Model of Osteoarthritis: Over-Expression of Smurf2 in Cartilage to Induce Disease and Over-expression of Smurf1 as a Potential Therapeutic Strategy
Applications:We have generated col2-promoter-Smad ubiquitin regulatory factor2 (col2-Smurf2) transgenic mice which possess a loss of TGFß signaling and display each of above characteristics, thus displaying a phenotype more representative of the disease process. Furthermore, the over-expression of Smurf2 in cartilage that has been induced in...
Published: 5/7/2024   |   Inventor(s): Randy Rosier, Michael Zuscik, Qiugian Wu, Edward Schwarz
Keywords(s): Diagnostic, Therapy
Category(s): Research Tools