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Generation of mutant mouse alleles that functionally disrupt production of BDNF from its ndividual promoters
This technology relates to a mouse model that improves an existing method of disrupting the production of the BDNF protein in specific parts of the brain. A current avenue of research seeks to examine how gene expression may effect long-lasting changes in the nervous system. Previous work has resulted in a mouse line in which the production of BDNF...
Published: 10/28/2024   |   Inventor(s): Keri Martinowich
Keywords(s): ALLELES, AXXXXX, BDNF, DISRUPT, FUNCTIONALLY, Generation, Indiividual, Mouse, MUTANT, NC4XXX, NCXXXX, production, PROMOTERS, That, VEXXXX, WIXXXX, XEXXXX
Category(s): TherapeuticArea > Neurology, Application > Research Materials, Application > Therapeutics