Search Results - neurotransmitter

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A Nurr1-Knockout Mouse Model for Parkinson's Disease and Stem Cell Differentiation
The researchers have generated Nurr1-knockout mice via genomic locus inactivation using homologous recombination. Transcription factor Nurr1 is an obligatory factor for neurotransmitter dopamine biosynthesis in ventral midbrain. From a neurological and clinical perspective, it suggests an entirely new mechanism for dopamine depletion in a region where...
Published: 4/8/2024   |   Inventor(s): Vera Nikodem
Keywords(s): AC5XXX, ACXXXX, Affected, AS..., AXXXXX, BAXXXX, BIOSYNTHESIS, DIFFERENTIATION, Disease, Dopamine, DOPAMINERGIC, ESSENTIAL, factor, Midbrain, Neurons, NEUROTRANSMITTER, Nurr1, Obligatory, Parkinson disease 2, Parkinson disease 3, Parkinson disease 9, Parkinson disease, juvenile, autosomal recessive, Parkinsons, Region, TERMINAL, transcription, VENTRAL
Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts > Animal Models
Molecular Cloning and Characterization of SNAPIN: A Synaptic Vesicle Protein Implicated in Neurotransmitter
Neurotransmitter release is dependent on a binding complex (designated as SNAR) of three proteins, synaptic-vesicle-associated protein synaptobrevin/VAMP, syntaxin and SNAP-25 (snaptosome-associated protein-25) with results in a calcium dependent fusion between synaptic vesicles and the presynaptic terminal. SNAPIN, a neuron specific protein found...
Published: 4/8/2024   |   Inventor(s): Jeffrey Ilardi, Zu-hang Sheng
Keywords(s): ac5AXX, AC5XXX, ACXXXX, AXXXXX, CHARACTERIZATION, Cloning, implicated, Listed LPM Maddox as of 4/15/2015, Molecular, NEUROTRANSMITTER, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Protein, Snapin:, SYNAPTIC, VESICLE
Category(s): Collaboration Sought > Licensing