Search Results - mobin+karimi

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β-Catenin agonists recapitulate the protective effects of genetic stabilization
This technology uses drugs that stabilize β-catenin to boost protective immune cells in the lungs, reducing damage from pulmonary hemorrhage and inflammatory lung diseases by activating a novel immunomodulatory pathway. Background: Pulmonary hemorrhage and other inflammatory lung diseases represent significant clinical challenges due to their...
Published: 3/24/2026   |   Updated: 3/24/2026   |   Inventor(s): Mobin Karimi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering
Harnessing IL15C and NKG2D for Potent and Persistent CAR T Cell Therapy in TNBC
This technology is an advanced CAR T-cell therapy for triple-negative breast cancer that uses engineered T-cells to recognize and kill cancer cells regardless of HLA status and includes a built-in IL-15 signal to boost T-cell survival and effectiveness. Background: Triple-Negative Breast Cancer (TNBC) is a particularly aggressive subtype of breast...
Published: 3/24/2026   |   Updated: 3/24/2026   |   Inventor(s): Mobin Karimi
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Biomedical Science and Engineering
Inhibition of ITK by Novel SLP76pTYR Targeted Only ITK Signaling and Enhanced Tregs
­Facilitates graft-versus-leukemia effect (GVL) while minimizing graft-versus-host disease (GVHD). Background: Graft versus host disease (GVHD) remains the second leading cause of death following allogeneic hematopoietic stem cell transplant (allo-HCT). In allo-HCT, mature donor T cells in the donor inoculum play a central role in mediating...
Published: 3/18/2026   |   Updated: 5/13/2025   |   Inventor(s): Mobin Karimi, Alaji Bah
Keywords(s): Technologies
Category(s): Campus > Upstate Medical University, Technology Classifications, Technology Classifications > Healthcare