Search Results - microfluidics

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Microfluidic platforms for live-cell imaging and bio/pathomimetic tissue models
Background:Methodologies to image and quantify tissue models using high-content analysis (HCI) and functional analyses of 3D avatars are needed as such avatars better recapitulate the phenotype of pathobiological processes and better predict efficacy of, and resistance to, a wide variety of therapies. Furthermore, changes in morphometry, viability,...
Published: 2/14/2022   |   Inventor(s): Bonnie Sloane, Kamiar Moin, Kyungmin Ji, Kingsley Osuala, Yong Xu, Hongen Tu
Keywords(s):  
Category(s): Specialty compounds, Research tools, Oncology, Microfluidics, Life Science, Instrumentation, Imaging, Diseases, Devices, Cell lines
A Novel Organs-On-Chip Platform
Summary Vanderbilt researchers have created a new multi-organs-on-chip platform that comprises Perfusion Control systems, MicroFormulators, and MicroClinical Analyzers connected via fluidic networks. The real-time combination of multiple different solutions to create customized perfusion media and the analysis of the effluents from each well are both...
Published: 7/9/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Medical Devices, Microfluidics, Research Tools, Diagnostics
Modular and Stackable Microfluidic Devices
SummaryVanderbilt researchers have invented a modular microfluidic bioreactor that can be layered and stacked to create complex organ-on-chip systems that mimic the behavior of human organ systems such as the neurovascular unit. This modular device can also be assembled from separate, functioning biolayers, and at the end of a study disassembled for...
Published: 7/9/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Microfluidics
Organ-on-a-Chip System
SummaryVanderbilt researchers have developed a group of microfluidic organ-on-chip devices that include perfusion controllers, microclinical analyzers, microformulators, and integrated microfluidic measurement chips. Together, these devices can measure and control multiple organ-on-chip systems in order to model the multi-organ physiology of humans.Addressed...
Published: 7/9/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Microfluidics
Low-cost, Normally Closed Microfluidic Valve
SummaryVanderbilt researchers have developed a normally closed valve that is able to provide selective movement of small fluid quantities in a microfluidic device. The present microfluidic valve can be actuated using a simple rotating drivehead and mechanical support, greatly simplifying the valve design.Addressed NeedMicrofluidics is a rapidly growing...
Published: 7/9/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Diagnostics, Microfluidics
I-Wire: A Biotension Measurement Device for Tissue Engineering and Pharmacology
Summary Vanderbilt researchers have developed an integrated system (“I-Wire”) for the growth of miniature, engineered 3D cardiac or other muscle or connective tissues and their active and passive mechanical characterization. The system utilizes an inverted microscope to measure the strain when the tissue constructs are laterally displaced...
Published: 7/9/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Diagnostics, Microfluidics
Marangoni Optofluidic Tweezers (MOT)
There is currently a great deal of interest in using small droplets as containers for chemical reactions. Optical methods for droplet manipulation are attractive because they offer control without an on chip structure; however forces from optical tweezers tend to be in the pN range. Wayne State University researchers have developed a new method...
Published: 5/19/2017   |   Inventor(s): Amar Basu, Gopakumar Kamalakshakurup
Keywords(s):  
Category(s): MEMS, Microfluidics, Physical Sciences, Instrumentation, Optics & Photonics
Nano-beaker array formation process and its use for high-throughput loading and crystallization screening and other lab-on-the-chip applications
Wayne State University researchers have invented a novel process to make array patterns and its use for high-throughput screening of crystallization conditions, liquid solution applications, and other lab-on-the-chip applications. The formation process is a variation of “particle lithography” in which microparticles such as polystyrene microparticles...
Published: 9/17/2019   |   Inventor(s): Guangzhao Mao, Daniel Sobczynski, Sunxi Wang, Eugene Xhahysa, Pedram Jahanian
Keywords(s): Nanotechnology
Category(s): Physical Sciences, Microfluidics, MEMS, Life Science, Research tools, Other
Rotary Planar Peristaltic Micropump (RPPM) and Rotary Planar Valve (RPV) for Microfluidic Systems
SummaryA Vanderbilt University research team led by Professor John Wikswo has developed low-cost, small-volume, metering peristaltic micropumps and microvalves. These pumps and valves can be used either as stand-alone devices incorporated into microfluidic subsystems, or as readily customized components for research or miniaturized point-of-care instruments,...
Published: 7/9/2024   |   Inventor(s): Parker Gould, Lloyd (Loi) Hoang, William Matloff, Kevin Seale, John Wikswo, Jr., Joseph Scherrer
Keywords(s):  
Category(s): Microfluidics, Medical Devices
Microfluidic Particle Concentration and Separator
Researchers at the Wayne State University Smart Sensors and Integrated Microsystems (SSIM) laboratory have developed a micro-scale concentrator and separator applicable to several microfluidic applications. Initially the device was developed to concentrate and separate bacteria from other impurities to test water quality however the micro separator...
Published: 9/10/2021   |   Inventor(s): Gregory Auner, Chung-Chu Chen
Keywords(s): Biotechnology
Category(s): Physical Sciences, Microfluidics, MEMS