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Search Results - marko+radic
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Precision Diagnostics: COVID-19 Severity Assessment via Advanced Plasma Biomarkers
24023-05: Precision Diagnostics: COVID-19 Severity Assessment via Advanced Plasma Biomarkers Inventor:
Marko Radic
, Ph.D. •COVID-19 patients who died had extensive damage to the elastin fibers in the lungs. •This suggests that neutrophil activity and elastin degradation play a crucial role in pulmonary fibrosis development. •High...
Published: 5/2/2024
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Inventor(s):
Marko Radic
Keywords(s):
Category(s):
Research Tools
Autoantibody to Heterogeneous Nuclear Ribonucleoprotein (hnRNP) P2
We generated spontaneous splenic B cell hybridomas and used microscopy to screen for clones reactive with apoptotic Jurkat cells. From hybridomas secreting IgG antibodies reactive with apoptotic cells, we selected one. The antibody, LHC7.15, bound to an antigen that is differentially distributed between the nucleus and the cytoplasm in live and apoptotic...
Published: 1/11/2023
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Inventor(s):
Marko Radic
,
Greg Lemke
Keywords(s):
Category(s):
Human Health
,
Research Tools
Recombinant Antibody Fusion Proteins and Methods for Detection of Apoptotic Cells
Apoptotic cells contain nuclear autoantigens that may initiate systemic autoimmune response. To explore the mechanism of antibody binding to apoptotic cells, 3H9, a murine autoantibody with dual specificity for phospholipids and DNA, was used. Heavy chain (H) mutants of 3H9 were constructed, expressed as single chain Fv (scFv) in E. coli, and assessed...
Published: 5/14/2024
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Inventor(s):
Marko Radic
,
Brian Cocca
Keywords(s):
Category(s):
Research Tools
,
Human Health