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Recombinant Antibody Fusion Proteins and Methods for Detection of Apoptotic Cells
Apoptotic cells contain nuclear autoantigens that may initiate systemic autoimmune response. To explore the mechanism of antibody binding to apoptotic cells, 3H9, a murine autoantibody with dual specificity for phospholipids and DNA, was used. Heavy chain (H) mutants of 3H9 were constructed, expressed as single chain Fv (scFv) in E. coli, and assessed...
Published: 5/14/2024   |   Inventor(s): Marko Radic, Brian Cocca
Keywords(s):  
Category(s): Research Tools, Human Health