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RNA virus attenuation by alteration of mutational robustness and sequence space
Summary RNA viruses pose serious threats to human health. Their success relies on their capacity to generate genetic variability and, consequently, on their adaptive potential. We describe a strategy to attenuate RNA viruses by altering their evolutionary potential. As an example, we rationally altered the genome of influenza A virus to redirect its...
Published: 2/14/2025   |   Inventor(s): Marco VIGNUZZI, Cyril BARBEZANGE, Gonzalo MORATORIO
Keywords(s): VACCINE
Category(s): Vaccines