Search Results - ligands

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Novel NMDA ligands that are specific and selective to the NR2B subunits based on the derivatives of 7-methoxy-3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-1-ol
This invention includes the design and synthesis of ligands that bind selectively and specifically to the NR2B subunit of the NMDA receptor. The NMDA receptor is thought to play a role in the pathophysiology of psychiatric disorders, including depression, stroke, drug addiction, and neuropathic pain. Existing ligands to the NMDA receptor are widely...
Published: 10/28/2024   |   Inventor(s): Victor Pike, Lisheng Cai
Keywords(s): 3, 4, 5-tetrahydro-1H-benzo[d]azepin-1-ol, 7-methoxy-3-4-phenylbutyl-2, Based, Derivatives, LIGANDS, NR2B, VNXXXX, WIXXXX
Category(s): Application > Research Materials, TherapeuticArea > Psychiatry/Mental Health
A Novel Scaffold for Multivalent Display of Ligands
Multivalent interactions are important in cell attachment, wound healing and immune responses. Such interactions are associated with cancer metastasis, blood clotting and the generation of antibodies from a vaccination. Mimicking multivalent interactions on a synthetic scaffold is challenging especially when large numbers of ligands (such as 5 or more)...
Published: 10/28/2024   |   Inventor(s): Daniel Appella
Keywords(s): AAXXXX, AXXXXX, Based, Chain-Modified, DISPLAY, LIGANDS, MULTIVALENT, Nanostructures, PNA, PNAfor, PROGRAMMABLE, Self-assembled, SIDE, Sidechain-Modified, YXXXXX
Category(s): Collaboration Sought > Collaboration
Reversible SNAP-Tag and CLIP-Tag Ligands for Live Cell Imaging
Recently-developed protein tags enable the specific covalent attachment of synthetic ligands, incorporating fluorophores or other substituted groups, to fusion proteins containing these tags. For example, SNAP and CLIP tags bind O6-benzylguanine-containing and O2-benzylcytosine containing ligands respectively, which can be derivatized with a wide variety...
Published: 4/8/2024   |   Inventor(s): Julie Donaldson, Nelson Cole
Keywords(s): ACXXXX, AXXXXX, CLIP, CLIP-tag, fluorescent, Fluorescent probe, IMAGING, LIGANDS, Patent Category - Biotechnology, REVERSIBLE, SNAP, SNAP-tag, Trafficking
Category(s): Collaboration Sought > Licensing
Therapeutic Methods Based on In Vivo Modulation of the Production of Interferon gamma
The technology offered for licensing is in the field of Therapeutics. More specifically, the technology relates to biological ligands and their use as modulators of the production of Interferon gamma as a means to treat a broad spectrum of diseases. The invention describes and claims antibodies and other ligands that can stimulate Natural Killer (NK)...
Published: 10/28/2024   |   Inventor(s): Sumati (Sumi) Rajagopalan, Eric Long
Keywords(s): Against, antibodies, DB3XXX, DB4XXX, DBXXXX, DC1XXX, DCXXXX, Directed, DXXXXX, Gamma, INTERFERON, KIR2DL4, LIGANDS, Patent Category - Biotechnology, production, RECEPTOR
Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Infectious Disease, Application > Vaccines