Search Results - life+sciences+%3e+therapeutics+%3e+gene+editing

3 Results Sort By:
Polymer-based nanoparticle system for gene editing and therapy delivery in cystic fibrosis
The invention is a non-viral gene delivery system using PEG-bound chitosan nanoparticles to deliver CRISPR/Cas9 components, enhancing cellular uptake and stability while being biocompatible and biodegradable, to correct cystic fibrosis mutations. Background Cystic fibrosis (CF) is a genetic disorder caused by mutations in the cystic fibrosis transmembrane...
Published: 11/11/2024   |   Inventor(s): Hugh Smyth, Hairui Zhang, Silvia Ferrati
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics > Gene editing
Improving the microbiome health of bees
Genetically engineered bacteria from the microbiome of bees are used to produce RNA interference (RNAi) molecules and other genetic tools to target and downregulate specific genes in bees or their pathogens. By reducing pathogen loads and altering gene expression of bees, this technology can combat threats to bee population, like colony collapse disorder,...
Published: 9/11/2024   |   Inventor(s): Nancy Moran, Jeffrey Barrick, Sean Leonard
Keywords(s):  
Category(s): Life sciences > Agriculture > Animal/veterinary, Life sciences > Therapeutics > Gene editing
Fusion protein technology for site‑specific integration of RNA into DNA genomes
The technology integrates target RNA into DNA genomes by adding short DNA tails to RNA. Direct RNA integration into CRISPR arrays eliminates the use of harsh transfection methods that fragment DNA sequences. Background The development of CRISPR-Cas systems, which are widely used for precise genetic modifications, has advanced the field of genome...
Published: 7/25/2024   |   Inventor(s): Alan Lambowitz, Georg Mohr
Keywords(s):  
Category(s): Life sciences, Life sciences > Therapeutics > Gene editing