Search Results - life+sciences+%3e+therapeutics+%3e+drug+discovery

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Sulfonyl-triazole activators for cell-selective glycolysis enhancement in cancer and Parkinson’s disease
Background Cellular metabolism is a central regulator of immune cell function and neuronal survival, making it a promising therapeutic target in both cancer and neuro­degenerative disease. In solid tumors, tumor-infiltrating lymphocytes (TILs) frequently succumb to metabolic exhaustion due to the nutrient-depleted and immunosuppressive microenvironment,...
Published: 1/27/2026   |   Inventor(s): Ku-Lung Hsu, Xiaoding Jiang, Xiaolu Cambronne
Keywords(s):  
Category(s): Life sciences > Therapeutics > Formulation, Life sciences > Therapeutics > Drug discovery
Microneedle array coating technology for enhanced stability and targeted delivery of mRNA and biologics
A microneedle-based system uses cryogenically pre-cooled needles coated via thin-film freeze-coating to preserve mRNA stability, enabling efficient, multi-therapeutic intradermal delivery of temperature-sensitive drugs. Background The field of advanced drug delivery systems has grown substantially as the biomedical industry grapples with the complexities...
Published: 1/27/2026   |   Inventor(s): Zhengrong Cui, Michael Sandoval, Robert Williams, Drew Weissman, Qin Li
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug discovery
Advanced hot melt extrusion (HME) technology with reduced decomposition
The technology involves using hot melt extrusion (HME) to prepare amorphous drug formulations with reduced decomposition. This method incorporates a pharmaceutically acceptable thermoplastic polymer and an organic solvent to lower processing temperatures and stress, ensuring drug stability. Background HME is a widely used technique in the pharmaceutical...
Published: 1/13/2026   |   Inventor(s): Feng Zhang, Robert Williams, Abbe Miller, Siyuan Huang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug discovery, Life sciences > Biomaterials