Search Results - life+sciences+%3e+therapeutics+%3e+drug+discovery

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Yeast-based screening platform for rapid identification of GPCR agonists
This invention is a yeast-based screening platform that uses tethered peptide libraries to identify human GPCR agonists quickly and cost-effectively, yielding receptor-specific ligands and valuable insights into GPCR drug discovery. Background The field of receptor pharmacology and drug discovery continues to seek improved methods for reliably identifying...
Published: 3/4/2025   |   Inventor(s): Andrew Ellington, Colleen Mulvihill, Jimmy Gollihar, Elizabeth Gardner, Edward Marcotte
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug screening, Life sciences > Therapeutics > Drug discovery
Advanced hot melt extrusion (HME) technology with reduced decomposition
The technology involves using hot melt extrusion (HME) to prepare amorphous drug formulations with reduced decomposition. This method incorporates a pharmaceutically acceptable thermoplastic polymer and an organic solvent to lower processing temperatures and stress, ensuring drug stability. Background HME is a widely used technique in the pharmaceutical...
Published: 9/10/2024   |   Inventor(s): Feng Zhang, Robert Williams, Abbe Miller, Siyuan Huang
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug discovery, Life sciences > Biomaterials