Search Results - jing+shaw

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Vaccine Attenuation via Deoptimization of Synonymous Codons

Research scientists at CDC have developed compositions and methods that can be used to develop attenuated vaccines having well-defined levels of replicative fitness and enhanced genetic stabilities. Infections by intracellular pathogens, such as viruses, bacteria, and parasites, are cleared in most cases after activation of specific T-cell immune responses...

Published: 10/28/2024 | Inventor(s): Cara Burns, Jacueline Quay, Jing Shaw, Olen Kew

Keywords(s): CDC Docket Import, CDC Docket Import CDC Prosecuting, CODONS, DC2XXX, DC4XXX, DC5XXX, DCXXXX, Deoptimization, DXXXXX, Fitness, Modulation, OID-NCIRD-DVD, Replicative, Synonymous, VBXXXX, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WAXXXX, WHXXXX, WIXXXX, WJXXXX, WMXXXX, XEXXXX, XHXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, ResearchProducts > Research Equipment, Application > Vaccines, TherapeuticArea > Infectious Disease, Application > Diagnostics, Application > Consumer Products, Application > Research Materials, Application > Therapeutics

Immune-Activated Genome-Edited Cancer Vaccines for Next-Generation Immunotherapy

This technology introduces a genome-edited whole-cell cancer vaccine engineered to remove key immune evasion signals such as CD47, enabling robust macrophage activation and enhanced antigen presentation. The edited, non-replicating tumor cells stimulate durable, systemic anti-tumor immunity with fewer off-target effects than antibody-based checkpoint...

Published: 11/21/2025 | Inventor(s): Kaiming Ye, Sha Jin, Subhadra Jayaraman Rukmini

Keywords(s):

Category(s): Technology Classifications > Biomedical Science and Engineering, Campus > Binghamton University

Decellularized Matrix Technology for Functional, Vascularized Pancreatic Islet Organoids

This invention uses a detergent-free decellularized pancreatic extracellular matrix (dpECM) to direct human pluripotent stem cells into self-assembled, vascularized pancreatic islet organoids. By recreating the native pancreatic microenvironment, the technology promotes β-cell maturation, multicellular organization, and glucose-responsive insulin...

Published: 11/26/2025 | Inventor(s): Sha Jin, Kaiming Ye, Huanjing Bi

Keywords(s): #SUNYresearch, Technologies

Category(s): Technology Classifications > Biomedical Science and Engineering, Campus > Binghamton University