Search Results - jianjing+cao

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Analogues of Modafinil for treating sleep and attention disorders
Abstract: Modafinil has attracted attention for the treatment of cognitive dysfunction in disorders such as attention-deficit/hyperactivity disorder (ADHD) as well as cocaine and methamphetamine dependence.  However, modafinil has relatively low affinity for binding to the dopamine transporter (DAT) to block dopamine reuptake, and is water-insoluble,...
Published: 4/8/2024   |   Inventor(s): Amy Newman, Oluyomi Okunola-Bakare, Jianjing Cao
Keywords(s): attention deficit/hyperactivity disorder (ADHD), dopamine (DAT), Modafinil, Narcolepsy, norepinephrine (NET), serotonin (SERT)
Category(s): Application > Therapeutics, Collaboration Sought > Licensing
Atypical Inhibitors of Monoamine Transporters; Method of Making; and Use Thereof
Abstract: Substance use disorder is a chronic medical condition, taking its toll on our public health care and judicial systems in an economically unsustainable way.  More than 20 million Americans suffer from substance use disorders. Certainly, the development of prevention and treatment options as alternatives to incarceration is the appropriate and...
Published: 4/8/2024   |   Inventor(s): Amy Newman, JoLynn Giancola, Rachel Slack, Jianjing Cao
Keywords(s): ADHD, dopamine reuptake inhibitor, Newman, sleep disorders, Substance use disorder
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Neurology
Novel Dopamine Receptor Ligands As Therapeutics For Central Nervous System Disorders
Abstract: The National Institute on Drug Abuse's Medications Discovery Research Branch is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize 4-phenylpiperazine derivatives as dopamine D3 selective ligands. The dopamine D3 receptor subtype is a member of the dopamine...
Published: 4/8/2024   |   Inventor(s): Amy Newman, Peter Grundt, Jianjing Cao, Robert Luedtke, George Cyriac
Keywords(s):  
Category(s): Application > Research Materials, TherapeuticArea > Gastroenterology, Collaboration Sought > Licensing
Small Molecule Degraders of EZH2 for the Treatment of Cancer
Thank you for your interest in this technology. Please see our technology brief here: https://app.in-part.com/articles/RQx7nmb60ZeM
Published: 10/23/2024   |   Inventor(s): Jian Jin, Ramon Parsons, Ilias Stratikopoulos, Xiaobao Yang, Anqi Ma
Keywords(s):  
Category(s): Therapeutic
Bi-Functional RGD Peptide and a Co-Signaling Mechanism to Promote Therapeutic Angiogenesis
Bi-Functional RGD Peptide to Promote Therapeutic Angiogenesis, Treat Ischemic Diseases Technology: While previous studies have focused on the identification of biological ligands to improve the functions of endothelial cells, MUSC and Clemson University researchers have combined modern bioinformatics and a newly established peptide functionalized...
Published: 3/23/2023   |   Inventor(s): Chung-Jen (James) Chou, Ying Mei, Jia Jia
Keywords(s):  
Category(s): BioPharma