Search Results - j+silvio+gutkind

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mTOR Inhibition for the Prevention of Epithelial Stem Cell Loss and Mucositis
The integrity of the epidermis and mucosal epithelia is highly dependent on self-renewing stem cells and, therefore, is vulnerable to physical and chemical damage from common cancer treatments, such as radiation or chemotherapy. Consequently, many cancer patients undergoing these treatments develop mucositis, a debilitating condition involving painful...
Published: 10/28/2024   |   Inventor(s): Ramiro Iglesias-Bartolome, Vyomesh Patel, Ana Cotrim, Alfredo Molinolo, James Mitchell, J Silvio Gutkind
Keywords(s): CBXXXX, Cell, CXXXXX, Epithelial, inhibition, mTOR, Mucositis, PREVENTS, PROTECTS, Radiation-induced, Senescence, Stem
Category(s): Application > Therapeutics, TherapeuticArea > Oncology
Diagnostic Biomarker of Metastasis for Improved Clinical Management of Head and Neck Cancer
Squamous Cell Carcinoma of the Head and Neck (HNSCC) is associated with poor prognosis due to the advanced stage of disease (metastasis) typically found at the time of diagnosis. Investigators at the NIH have developed a sensitive method using a protein biomarker for detecting even just a few HNSCC tumor cells in lymph nodes with occult disease. Combination...
Published: 10/28/2024   |   Inventor(s): J Silvio Gutkind
Keywords(s): Biomarker, CA1XXX, Carcinoma, squamous cell of head and neck, CAXXXX, CXXXXX, Detection, DSG3, Identification, lymph, MEN 1, Metastasis, nodes, OCCULT, Patent Category - Biotechnology, Sentinel, Squamous cell carcinoma, Squamous cell carcinoma of the head and neck, Zollinger-Ellison syndrome
Category(s): Application > Diagnostics, TherapeuticArea > Oncology
Prevention of Head and Neck Cancer Using Rapamycin and Its Analogs
It is frequently observed in head and neck squamous cell carcinoma (HNSCC), a cancer occurring mostly in the mouth, that the Akt/mTOR pathway is abnormally activated. Therefore, inhibiting this signaling pathway may help in treating this disease. Rapamycin and its analogs are known to inhibit the activity of mTOR so in principle they could serve as...
Published: 10/28/2024   |   Inventor(s): Panomwat Amornphimoltham, Rakefet Czerninski, Vyomesh Patel, Alfredo Molinolo, J Silvio Gutkind
Keywords(s): (4)r syndrome, C syndrome, Carcinoma, CBXXXX, CHEMOPREVENTIVE, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, Cowden's disease, Cowden's syndrome, CXXXXX, G syndrome, HEAD, Hypertelorism with esophageal abnormality and hypospadias, Listed LPM Campbell as of 4/15/2015, MTOR-inhibitors, N syndrome, NECK, Patent Category - Biotechnology, Patent Category - Chemistry, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, R(6) syndrome, R(7) syndrome, Rapamycin, SQUAMOUS, Squamous cell carcinoma, Syndrome X, W syndrome, W syndrome; Syndrome W
Category(s): Application > Therapeutics, TherapeuticArea > Oncology