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Renal Selective Unsaturated Englerin Analogues
Abstract: Englerin A, a natural product, has shown growth-inhibiting activity against renal cancer cell lines. The compound is an agonist of protein kinase C (PCK) theta, which results in cell cytotoxicity, insulin inhibition, and selective activation of viral replication in T cells.  Englerin A derivatives are promising treatment strategies for any...
Published: 4/8/2024   |   Inventor(s): John Beutler, Tanya Ransom, Antonio Echavarren, Frederic Ratel
Keywords(s): Beutler, DIABETES, HIV, renal cancer, small molecule
Category(s): TherapeuticArea > Endocrinology, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease