Search Results - edward+cox

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Safer Attenuated Virus Vaccines with Missing or Diminished Latency of Infection

This technology describes recombinant viruses that have weakened ability to establish and/or maintain latency and their use as live vaccines. The viruses have one or more genetic mutations that allow for continued replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the virus that causes...

Published: 10/28/2024 | Inventor(s): Lesley Pesnicak, Edward Cox, Jeffrey Cohen

Keywords(s): BUT, chickenpox, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Impaired, Latency, MUTANT, Patent Category - Biotechnology, REPLICATION, UAXXXX, Vaccine, VARICELLA-ZOSTER

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases, Application > Vaccines

A method for measuring and modeling quantitative sequence-function relationships for possible applications in transcriptional misregulation, antibody optimization, and antigenic epitope development

Princeton University Invention # 10-2580 Researchers in the Physics and Molecular Biology Departments, Princeton University, have developed a method that uses a simple mutational assay and information theory to decipher the molecular mechanisms by which a biological sequence functions, either in vitro or in living cells. This technology was demonstrated...

Published: 3/30/2022 | Inventor(s): Justin b. Kinney, Edward Cox, Curtis Callan, Anand Murugan

Keywords(s):

Category(s): Biotechnology/Pharmaceuticals

An Easy and Efficient Method for Engineering Large Synthetic Constructs into the Chromosome

Princeton University Invention # 10-2603 Researchers in the Department of Molecular Biology, Princeton University have developed an efficient, easy to use, two-step system for the site-directed insertion of large genetic constructs into arbitrary positions in the Escherichia coli chromosome. This system can also be used for the integration of...

Published: 3/30/2022 | Inventor(s): Thomas Kuhlman, Edward Cox

Keywords(s):

Category(s): Biotechnology/Pharmaceuticals