Search Results - david+heppner

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DUOX1 Inhibitors for Treatment of Allergic Disorders
Current treatments for allergic diseases such as asthma, atopic eczema and psoriasis are still not effective for 10% of the millions of patients worldwide with these diseases. Dual oxidase (DUOX1) is a member of the NADPH oxidase family and is a critical mediator of innate immune response to allergens. Several thiol-reactive electrophiles have been...
Published: 5/21/2025   |   Inventor(s): Albert van der Vliet, David Heppner, Karamatullah Danyal
Keywords(s):  
Category(s): Technology Classifications > Biomedical
Benzodiazepinone-derived Inhibitors of EGFR and HER2
A class of benzodiazepinone-derived molecules, inhibitors of both triple mutant EGFR and HER2, for cancer therapeutics or biochemical research tools. Background: Inhibition of epithelial growth factor receptor (EGFR) as a non-small cell lung cancer (NSCLC) therapeutic is not a new concept, but 75% of patients die within five years of diagnosis. As...
Published: 5/13/2025   |   Inventor(s): David Heppner, Stefan Laufer, Florian Wittlinger, Blessing Ogboo, Calvin Pham, Alexander Rasch
Keywords(s): Featured, Technologies
Category(s): Campus > University at Buffalo, Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Materials and Chemicals