Search Results - david+botstein

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Morpholino Oligomers to Prevent and Treat Coronavirus Infection
This technology licensing opportunity relates to antisense agents for treating or preventing a SARS-CoV-2 infection. The antisense agents are peptide-conjugated morpholino oligomers targeting pre-mRNA of a host (human) gene that encodes a protease. Some antisense agents included within the scope of this technology include agents previously shown to...
Published: 5/26/2021   |   Inventor(s): Hong Moulton, David Stein, Eva Bottcher-Friebershauser
Keywords(s):  
Category(s): Therapeutics
Antisense Agents for Treating SARS-CoV-2 Infection
Background In December 2019, cases of an acute respiratory disease were reported from Wuhan, the capital of Hubei province in China. The number of infections increased rapidly and spread to other areas of China and on January 13th, 2020, the first case was reported outside of China. The causative agent was identified as a novel coronavirus (CoV)...
Published: 7/31/2023   |   Inventor(s): David Stein, Hong Moulton, Kyle Rosenke, Heinrich Feldmann
Keywords(s): antisense, coronavirus, covid-19, Drug, SARS-CoV-2, Therapeutic
Category(s): Therapeutics
Genome-Wide mapping of Polymorphisms at Nucleotide Resolution with a Single DNA Array
Princeton Invention # 06-2269 A central challenge of genomics is to detect, simply and inexpensively, any and all differences in sequence among the genomes of individual members of a species. Researchers at the Lewis-Sigler Institute for Integrative Genomics, Princeton University , have devised a system using high-density Affymetrix yeast tiling...
Published: 3/30/2022   |   Inventor(s): Leonid Kruglyak, David Botstein, David Gresham, Douglas Ruderfer, Stephen Pratt
Keywords(s):  
Category(s): Biotechnology/Pharmaceuticals
Novel Gene Induction and Protein Degradation Systems: A rapid and specific tool for gene function studies and high throughput screening for target identification and drug discovery
Princeton Docket # 11-2672 Researchers at Princeton University have developed a novel system for the rapid and specific induction of individual genes, and upon modification, this system also allows for the rapid and specific degradation of target proteins. Substantial induction/degradation of target genes/proteins can be achieved within minutes...
Published: 12/15/2022   |   Inventor(s): Sanford Silverman, Robert Mcisaac, David Botstein, Marcus Noyes
Keywords(s): drug discovery, life science research tools, platform technology
Category(s): Biotechnology/Pharmaceuticals