Search Results - barry+byrne

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Improved Gene Therapy Vectors for the Treatment of Glycogen Storage Disease Type Ia (GSD-1a)
Abstract: GSD-Ia is an inherited disorder of metabolism associated with life-threatening hypoglycemia, hepatic malignancy, and renal failure caused by the deficiency of glucose-6-phosphatase-alpha (G6Pase-alpha or G6PC). Current therapy, which primarily consists of dietary modification, fails to prevent long-term complications in many patients, including...
Published: 4/8/2024   |   Inventor(s): Janice Chou, Barry Byrne
Keywords(s): Chou, GSD-1a, hepatic malignancy, hyperlipidemia, hypoglycemia, National Institute of Child Health and Human Development, NICHD
Category(s): TherapeuticArea > Nephrology, Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Endocrinology
Improved Large Scale Production of Adeno-Associated Viruses
Enables a More Efficient and More Potent Production of AAV VectorsThis production of highly concentrated and potent Adeno-Associated Virus (AAV) vectors has significant advantage over available protocol and allows for large-scale manufacturing of the virus. More than 6 percent of all gene therapy clinical trials worldwide use AAV vectors due to their...
Published: 6/27/2021   |   Inventor(s): Barry Byrne, Nathalie Clement, Laura Adamson
Keywords(s): AAV, Gene Therapy, HEK293, HSV
Category(s): Technology Classifications > Human Health Care > Gene Therapy
Purification of AAV Serotypes Using Off-the-Shelf Reagents
Purification Protocol Is Easily Adaptable to Large-Scale Manufacturing of Versatile, Successful Gene Therapy Delivery VehiclesThis purification of recombinant adeno-associated virus serotype three (rAAV3), eight (rAAV8) and nine (rAAV9) uses inexpensive, efficient reagents and is easily adaptable to large-scale manufacturing. An AAV is a small nonenveloped...
Published: 6/27/2021   |   Inventor(s): Barry Byrne, Mark Potter
Keywords(s): Gene Therapy, Purification, rAAV, Serotype nine
Category(s): Technology Classifications > Human Health Care > Gene Therapy, Technology Classifications > Research Tools > Therapeutics